Department of Medicinal Chemistry

Department of Medicinal ... Research groups Theranostics Publications

Publication list

List of publications in date order

Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with Tc-99m and I-125

Tolmachev, Vladimir; Bodenko, Vitalina; Orlova, Anna; Schulga, Alexey et al.

Part of Oncology Letters, 2023.

DOI for Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with Tc-99m and I-125 Download full text (pdf) of Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with Tc-99m and I-125

Open access
Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts

Oroujeni, Maryam; Tano, Hanna; Vorobyeva, Anzhelika; Liu, Yongsheng et al.

Part of Journal of Nuclear Medicine, p. 1046-1051, 2022.

DOI for Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts
Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands

Lundmark, Fanny; Olanders, Gustav; Rinne, Sara Sophie; Abouzayed, Ayman et al.

Part of Pharmaceutics, 2022.

DOI for Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands Download full text (pdf) of Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands

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Direct In Vivo Comparison of ^99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy

Tolmachev, Vladimir; Bodenko, Vitalina; Oroujeni, Maryam; Deyev, Sergey et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Direct In Vivo Comparison of ^99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy Download full text (pdf) of Direct In Vivo Comparison of ^99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy

Open access
Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Xu, Tianqi; Zhang, Jie; Oroujeni, Maryam; Tretyakova, Maria S. et al.

Part of Pharmaceutics, 2022.

DOI for Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2 Download full text (pdf) of Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

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Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Part of Pharmaceutics, 2022.

DOI for Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3 Download full text (pdf) of Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

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Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart

Garousi, Javad; Xu, Tianqi; Liu, Yongsheng; Vorontsova, Olga et al.

Part of Pharmaceutics, 2022.

DOI for Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart Download full text (pdf) of Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart

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Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

Liu, Yongsheng; Vorobyeva, Anzhelika; Orlova, Anna; Konijnenberg, Mark W. et al.

Part of Pharmaceutics, 2022.

DOI for Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071 Download full text (pdf) of Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

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Phase I Trial of ^99mTc-(HE)₃-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer

Bragina, Olga; Chernov, Vladimir; Schulga, Alexey; Konovalova, Elena et al.

Part of Journal of Nuclear Medicine, p. 528-535, 2022.

DOI for Phase I Trial of ^99mTc-(HE)₃-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer
Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Liu, Yongsheng; Yu, Shengze; Xu, Tianqi; Bodenko, Vitalina et al.

Part of Pharmaceutics, 2022.

DOI for Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT Download full text (pdf) of Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Open access
Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules

Rinne, Sara S.; Yin, Wen; Borras, Anna Mestre; Abouzayed, Ayman et al.

Part of Biomedicines, 2022.

DOI for Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules Download full text (pdf) of Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules

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The Performance of FDA-Approved PET Imaging Agents in the Detection of Prostate Cancer

Li, Mei; Zelchan, Roman; Orlova, Anna

Part of Biomedicines, 2022.

DOI for The Performance of FDA-Approved PET Imaging Agents in the Detection of Prostate Cancer Download full text (pdf) of The Performance of FDA-Approved PET Imaging Agents in the Detection of Prostate Cancer

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A method of drug delivery to tumors based on rapidly biodegradable drug-loaded containers

Parakhonskiy, Bogdan, V; Shilyagina, Natalia Yu; Gusliakova, Olga, I; Volovetskiy, Artur B. et al.

Part of APPLIED MATERIALS TODAY, 2021.

DOI for A method of drug delivery to tumors based on rapidly biodegradable drug-loaded containers
Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

Ding, Haozhong; Xu, Tianqi; Zhang, Jie; Tolmachev, Vladimir et al.

Part of Pharmaceutics, 2021.

DOI for Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution Download full text (pdf) of Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

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Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting

Tano, Hanna; Oroujeni, Maryam; Vorobyeva, Anzhelika; Westerlund, Kristina et al.

Part of Cancers, 2021.

DOI for Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting Download full text (pdf) of Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting

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Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Liu, Yongsheng; Vorobyeva, Anzhelika; Xu, Tianqi; Orlova, Anna et al.

Part of Pharmaceutics, 2021.

DOI for Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain Download full text (pdf) of Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Open access
Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model

Xu, Tianqi; Ding, Haozhong; Vorobyeva, Anzhelika; Oroujeni, Maryam et al.

Part of Cancers, 2021.

DOI for Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model Download full text (pdf) of Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model

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Ga-66-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [Ga-66]Ga-NOTA-PEG(2)-RM26

Rinne, Sara S.; Abouzayed, Ayman; Gagnon, Katherine; Tolmachev, Vladimir et al.

Part of Scientific Reports, 2021.

DOI for Ga-66-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [Ga-66]Ga-NOTA-PEG(2)-RM26 Download full text (pdf) of Ga-66-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [Ga-66]Ga-NOTA-PEG(2)-RM26

Open access
HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers

Rinne, Sara S.; Dahlsson Leitao, Charles; Abouzayed, Ayman; Vorobyeva, Anzhelika et al.

Part of Cancers, p. 4791-4791, 2021.

DOI for HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers Download full text (pdf) of HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers

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Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model

Xu, Tianqi; Vorobyeva, Anzhelika; Schulga, Alexey; Konovalova, Elena et al.

Part of Cancers, 2021.

DOI for Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model Download full text (pdf) of Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model

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Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1

Deyev, Sergey M.; Xu, Tianqi; Liu, Yongsheng; Schulga, Alexey et al.

Part of Cancers, 2021.

DOI for Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1 Download full text (pdf) of Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1

Open access
PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology

Rinne, Sara S.; Orlova, Anna; Tolmachev, Vladimir

Part of International Journal of Molecular Sciences, 2021.

DOI for PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology Download full text (pdf) of PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology

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Phase I study of ^99mTc-ADAPT6, a scaffold protein-based probe for visualization of HER2 expression in breast cancer

Bragina, Olga; von Witting, Emma; Garousi, Javad; Zelchan, Roman et al.

Part of Journal of Nuclear Medicine, p. 493-499, 2021.

DOI for Phase I study of ^99mTc-ADAPT6, a scaffold protein-based probe for visualization of HER2 expression in breast cancer
Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use

Bragina, O. D.; Chernov, V. I.; Garbukov, E. Yu; Doroshenko, A. V. et al.

Part of Bûlleten' sibirskoj mediciny, p. 23-30, 2021.

DOI for Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use Download full text 1 (pdf) of Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use Download full text 2 (pdf) of Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use

Open access
Preclinical Evaluation of ^99mTc-Labeled GRPR Antagonists maSSS/SES-PEG₂-RM26 for Imaging of Prostate Cancer

Abouzayed, Ayman; Rinne, Sara S.; Sabahnoo, Hamideh; Sörensen, Jens et al.

Part of Pharmaceutics, 2021.

DOI for Preclinical Evaluation of ^99mTc-Labeled GRPR Antagonists maSSS/SES-PEG₂-RM26 for Imaging of Prostate Cancer Download full text (pdf) of Preclinical Evaluation of ^99mTc-Labeled GRPR Antagonists maSSS/SES-PEG₂-RM26 for Imaging of Prostate Cancer

Open access
Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Oroujeni, Maryam; Rinne, Sara S.; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Part of International Journal of Molecular Sciences, 2021.

DOI for Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake Download full text (pdf) of Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Open access
Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle

Garousi, Javad; von Witting, Emma; Borin, Jesper; Vorobyeva, Anzhelika et al.

Part of Biomaterials, 2021.

DOI for Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle Download full text (pdf) of Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle

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Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein

Garousi, Javad; Ding, Haozhong; von Witting, Emma; Xu, Tianqi et al.

Part of Pharmaceutics, 2021.

DOI for Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein Download full text (pdf) of Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein

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The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer

Tolmachev, Vladimir; Orlova, Anna; Sörensen, Jens

Part of Seminars in Cancer Biology, p. 185-197, 2021.

DOI for The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer
The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy

Yin, Wen; Xu, Tianqi; Altai, Mohamed; Oroujeni, Maryam et al.

Part of Pharmaceutics, 2021.

DOI for The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy Download full text (pdf) of The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy

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The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR: 2377 Affibody Molecule

Oroujeni, Maryam; Xu, Tianqi; Gagnon, Katherine; Rinne, Sara S. et al.

Part of Pharmaceutics, 2021.

DOI for The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR: 2377 Affibody Molecule Download full text (pdf) of The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR: 2377 Affibody Molecule

Open access
Affibody Molecules as Targeting Vectors for PET Imaging

Tolmachev, Vladimir; Orlova, Anna

Part of Cancers, 2020.

DOI for Affibody Molecules as Targeting Vectors for PET Imaging Download full text (pdf) of Affibody Molecules as Targeting Vectors for PET Imaging

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Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules

Rinne, Sara S.; Leitao, Charles Dahlsson; Saleh-nihad, Zahra; Mitran, Bogdan et al.

Part of International Journal of Molecular Sciences, 2020.

DOI for Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules Download full text (pdf) of Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules

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Effect of a radiolabel biochemical nature on tumor-targeting properties of EpCAM-binding engineered scaffold protein DARPin Ec1

Deyev, Sergey M.; Vorobyeva, Anzhelika; Schulga, Alexey; Abouzayed, Ayman et al.

Part of International Journal of Biological Macromolecules, p. 216-225, 2020.

DOI for Effect of a radiolabel biochemical nature on tumor-targeting properties of EpCAM-binding engineered scaffold protein DARPin Ec1 Download full text (pdf) of Effect of a radiolabel biochemical nature on tumor-targeting properties of EpCAM-binding engineered scaffold protein DARPin Ec1

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Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model.

Leitao, Charles Dahlsson; Rinne, Sara S.; Altai, Mohamed; Vorontsova, Olga et al.

Part of Pharmaceutics, 2020.

DOI for Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model. Download full text (pdf) of Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model.

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Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting

Myrhammar, Anders; Vorobyeva, Anzhelika; Westerlund, Kristina; Yoneoka, Shuichiro et al.

Part of Scientific Reports, 2020.

DOI for Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting Download full text (pdf) of Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting

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Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1

Vorobyeva, Anzhelika; Konovalova, Elena; Xu, Tianqi; Schulga, Alexey et al.

Part of International Journal of Molecular Sciences, 2020.

DOI for Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1 Download full text (pdf) of Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1

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HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution

Ding, Haozhong; Altai, Mohamed; Yin, Wen; Lindbo, Sarah et al.

Part of Pharmaceutics, 2020.

DOI for HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution Download full text (pdf) of HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution

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Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

Lundmark, Fanny; Abouzayed, Ayman; Mitran, Bogdan; Rinne, Sara S. et al.

Part of Pharmaceutics, 2020.

DOI for Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model Download full text (pdf) of Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

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Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Garousi, Javad; Orlova, Anna; Frejd, Fredrik Y.; Tolmachev, Vladimir

Part of EJNMMI Radiopharmacy and Chemistry, 2020.

DOI for Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Open access
Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches

Güler, Rezan; Svedmark, Siri Flemming; Abouzayed, Ayman; Orlova, Anna et al.

Part of Scientific Reports, 2020.

DOI for Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches Download full text (pdf) of Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches

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Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules

Rinne, Sara S.; Xu, Tianqi; Leitao, Charles Dahlsson; Stahl, Stefan et al.

Part of International Journal of Molecular Sciences, 2020.

DOI for Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules Download full text (pdf) of Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules

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Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer

Baun, Christina; Mitran, Bogdan; Rinne, Sara S.; Dam, Johan H. et al.

Part of Molecules, 2020.

DOI for Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer Download full text (pdf) of Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer

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Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer

Abouzayed, Ayman; Tano, Hanna; Nagy, Abel; Rinne, Sara S. et al.

Part of Pharmaceutics, 2020.

DOI for Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer Download full text (pdf) of Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer

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Radiolabeled GRPR Antagonists for Imaging of Disseminated Prostate Cancer: Influence of Labeling Chemistry on Targeting Properties

Mitran, Bogdan; Tolmachev, Vladimir; Orlova, Anna

Part of Current Medicinal Chemistry, p. 7090-7111, 2020.

DOI for Radiolabeled GRPR Antagonists for Imaging of Disseminated Prostate Cancer: Influence of Labeling Chemistry on Targeting Properties
Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1

Vorobyeva, Anzhelika; Bezverkhniaia, Ekaterina; Konovalova, Elena; Schulga, Alexey et al.

Part of Molecules, 2020.

DOI for Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1 Download full text (pdf) of Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1

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Affibody-mediated imaging of EGFR expression in prostate cancer using radiocobalt-labeled DOTA-Z(EGFR:2377)

Mitran, Bogdan; Andersson, Ken Gosta; Lindström, Elin; Garousi, Javad et al.

Part of Oncology Reports, p. 534-542, 2019.

DOI for Affibody-mediated imaging of EGFR expression in prostate cancer using radiocobalt-labeled DOTA-Z(EGFR:2377)
Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer

Mitran, Bogdan; Varasteh, Zohreh; Abouzayed, Ayman; Rinne, Sara S. et al.

Part of Cancers, 2019.

DOI for Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer Download full text (pdf) of Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer

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Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

Garousi, Javad; Huizing, Fokko J.; Vorobyeva, Anzhelika; Mitran, Bogdan et al.

Part of Scientific Reports, 2019.

DOI for Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts Download full text (pdf) of Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

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Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours

Garousi, Javad; Lindbo, Sarah; Borin, Jesper; von Witting, Emma et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 37-48, 2019.

DOI for Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours Download full text (pdf) of Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours

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