Publications

Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH

Das, Biswanath; Toledo-Carrillo, Esteban A.; Li, Guoqi; Stahle, Jonas et al.

Part of Journal of Materials Chemistry A, p. 13331-13340, 2023.

DOI for Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH Download full text (pdf) of Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH

A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane

Schembri, Luke S; Olaniran, Esther; Söderström, Marcus; Skillinghaug, Bobo et al.

Part of Advanced Synthesis and Catalysis, p. 1839-1845, 2023.

DOI for A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane Download full text (pdf) of A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane

Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents

Craig, Alexander J.; Ermolovich, Yuri; Cameron, Alan; Rodler, Agnes et al.

Part of ACS Medicinal Chemistry Letters, p. 802-809, 2023.

DOI for Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents

Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Caldeweyher, Eike; Elkin, Masha; Gheibi, Golsa; Johansson, Magnus et al.

Part of Journal of the American Chemical Society, p. 17367-17376, 2023.

DOI for Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Characterization of a Newly Available Coastal Marine Dissolved Organic Matter Reference Material (TRM-0522)

Felgate, Stacey L.; Craig, Alexander J.; Moodie, Lindon W. K.; Hawkes, Jeffrey

Part of Analytical Chemistry, p. 6559-6567, 2023.

DOI for Characterization of a Newly Available Coastal Marine Dissolved Organic Matter Reference Material (TRM-0522)

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Part of Scientific Reports, 2023.

DOI for Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma Download full text (pdf) of Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

Tannergren, Christer; Jadhav, Harshad; Eckernas, Emma; Fagerberg, Jonas et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 144-159, 2023.

DOI for Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging

Kaya, Ibrahim; Schembri, Luke S; Nilsson, Anna; Shariatgorji, Reza et al.

Part of Journal of the American Society for Mass Spectrometry, p. 836-846, 2023.

DOI for On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging Download full text (pdf) of On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging

Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

Garcia, Mauricio A.; Hensler, Gonul; Al-Gousous, Jozef; Pielenhofer, Jonas et al.

Part of Drug Metabolism and Pharmacokinetics, 2023.

DOI for Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

SPICY: a method for single scan rotating frame relaxometry

Tolkkinen, Katja; Mailhiot, Sarah; Selent, Anne; Mankinen, Otto et al.

Part of Physical Chemistry, Chemical Physics - PCCP, p. 13164-13169, 2023.

DOI for SPICY: a method for single scan rotating frame relaxometry Download full text (pdf) of SPICY: a method for single scan rotating frame relaxometry

[¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44

Cheung, Pierre; Amin, Mohammad A.; Zhang, Bo; Lechi, Francesco et al.

Part of Pharmaceutics, 2023.

DOI for [¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 Download full text (pdf) of [¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44

Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols

Zhang, Jianwei; Das, Biswanath; Verho, Oscar; Bäckvall, Jan-E.

Part of Angewandte Chemie International Edition, 2022.

DOI for Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols Download full text (pdf) of Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols

Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation

Das, Biswanath; Toledo-Carrillo, Esteban Alejandro; Li, Lin; Ye, Fei et al.

Part of ChemCatChem, 2022.

DOI for Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation

Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule

Grinkevich, Vera V.; Vema, Aparna; Fawkner, Karin; Issaeva, Natalia et al.

Part of Frontiers in Molecular Biosciences, 2022.

DOI for Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule Download full text (pdf) of Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule

Bacterial type I signal peptidase inhibitors-Optimized hits from nature

Szalaj, Natalia; Benediktsdottir, Andrea; Rusin, Dominika; Karlén, Anders et al.

Part of European Journal of Medicinal Chemistry, 2022.

DOI for Bacterial type I signal peptidase inhibitors-Optimized hits from nature

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Roy, Tamal; Petersen, Nadia N.; Gopalan, Greeshma; Gising, Johan et al.

Part of Bioorganic & Medicinal Chemistry, 2022.

DOI for 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands Download full text (pdf) of 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats Download full text (pdf) of Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Part of Journal of the American Chemical Society, p. 2905-2920, 2022.

DOI for Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses Download full text (pdf) of Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Dipolar Relaxation of Water Protons in the Vicinity of a Collagen-like Peptide

Karjalainen, Jouni; Henschel, Henning; Nissi, Mikko J.; Nieminen, Miika T. et al.

Part of Journal of Physical Chemistry B, p. 2538-2551, 2022.

DOI for Dipolar Relaxation of Water Protons in the Vicinity of a Collagen-like Peptide Download full text (pdf) of Dipolar Relaxation of Water Protons in the Vicinity of a Collagen-like Peptide

Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Safa, Neda; Trobec, Tomaz.; Holland, Darren C.; Slazak, Blazej et al.

Part of Journal of Natural Products, p. 215-224, 2022.

DOI for Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum Download full text (pdf) of Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats Download full text (pdf) of Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Part of Cells, 2022.

DOI for Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Download full text (pdf) of Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Brem, Jürgen; Panduwawala, Tharindi; Hansen, Jon Ulf; Hewitt, Joanne et al.

Part of Nature Chemistry, p. 15-24, 2022.

DOI for Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Part of ACS Infectious Diseases, p. 482-498, 2022.

DOI for Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2) Download full text (pdf) of Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Towards the sustainable discovery and development of new antibiotics

Miethke, Marcus; Pieroni, Marco; Weber, Tilmann; Brönstrup, Mark et al.

Part of Nature Reviews Chemistry, p. 726-749, 2021.

DOI for Towards the sustainable discovery and development of new antibiotics

A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Meineke, Birthe; Heimgärtner, Johannes; Craig, Alexander J.; Landreh, Michael et al.

Part of Frontiers in Chemistry, 2021.

DOI for A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling Download full text (pdf) of A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies

Mouhib, Mohammed; Benediktsdottir, Andrea; Svensson Nilsson, Caroline; Chi, Celestine N.

Part of ACS Omega, p. 24377-24381, 2021.

DOI for Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies Download full text (pdf) of Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies

The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation

Das, Biswanath; Rahaman, Ahibur; Shatskiy, Andrey; Verho, Oscar et al.

Part of Accounts of Chemical Research, p. 3326-3337, 2021.

DOI for The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation Download full text (pdf) of The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation

Organic reactivity from mechanism to machine learning

Jorner, Kjell; Tomberg, Anna; Bauer, Christoph; Sköld, Christian et al.

Part of Nature Reviews Chemistry, p. 240-255, 2021.

DOI for Organic reactivity from mechanism to machine learning

Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors

Akaberi, Dario; Bahlstrom, Amanda; Chinthakindi, Praveen K.; Nyman, Tomas et al.

Part of Antiviral Research, 2021.

DOI for Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors

A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal

Lati, Monireh Pourghasemi; Stahle, Jonas; Meyer, Michael; Verho, Oscar

Part of Journal of Organic Chemistry, p. 8527-8537, 2021.

DOI for A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal Download full text (pdf) of A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal

Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Benediktsdottir, Andrea; Lu, Lu; Cao, Sha; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, 2021.

DOI for Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation Download full text (pdf) of Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

ENABLE: an engine for European antibacterial drug discovery and development

Olliver, Marie; Griestop, Laura; Hughes, Diarmaid; Belfrage, Anna Karin et al.

Part of Nature reviews. Drug discovery, p. 407-408, 2021.

DOI for ENABLE: an engine for European antibacterial drug discovery and development

Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Olanders, Gustav; Brandt, Peter; Sköld, Christian; Karlen, Anders

Part of Bioorganic & Medicinal Chemistry, 2021.

DOI for Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs Download full text (pdf) of Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS

Yuan, Ning; Gudmundsson, Arnar; Gustafson, Karl P. J.; Oschmann, Michael et al.

Part of ACS Catalysis, p. 2999-3008, 2021.

DOI for Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS Download full text (pdf) of Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS

Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

Byrne, Liam; Sköld, Christian; Norrby, Per-Ola; Munday, Rachel H. et al.

Part of Advanced Synthesis and Catalysis, p. 259-267, 2021.

DOI for Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

Nyman, Julia; Guo, Ning; Sandström, Anja; Hallberg, Mathias et al.

Part of European Journal of Pharmacology, 2021.

DOI for The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

Carlström, Karl E.; Chinthakindi, Praveen K.; Espinosa, Belen; Al Nimer, Faiez et al.

Part of NEUROTHERAPEUTICS, p. 1142-1152, 2020.

DOI for Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate Download full text (pdf) of Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

Nanocatalysis Meets Biology

Verho, Oscar; Backvall, Jan-E.

Part of Nanoparticles in catalysis, p. 243-278, 2020.

DOI for Nanocatalysis Meets Biology

Phidianidine A and Synthetic Analogues as Naturally Inspired Marine Antifoulants

Labriere, Christophe; Elumalai, Vijayaragavan; Staffansson, Jannie; Cervin, Gunnar et al.

Part of Journal of Natural Products, p. 3413-3423, 2020.

DOI for Phidianidine A and Synthetic Analogues as Naturally Inspired Marine Antifoulants

Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease

Akaberi, Dario; Chinthakindi, Praveen K.; Båhlström, Amanda; Palanisamy, Navaneethan et al.

Part of Journal of Biomolecular Structure and Dynamics, p. 5526-5536, 2020.

DOI for Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease Download full text (pdf) of Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease

Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Part of ADMET & DMPK, p. 375-390, 2020.

DOI for Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models Download full text (pdf) of Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Turning Information Dissipation into Dissemination: Instagram as a Communication Enhancing Tool during the COVID-19 Pandemic and Beyond

Ye, Sofie; Hartmann, Rafael; Söderström, Marcus; Amin, Mohammad A. et al.

Part of Journal of Chemical Education, p. 3217-3222, 2020.

DOI for Turning Information Dissipation into Dissemination: Instagram as a Communication Enhancing Tool during the COVID-19 Pandemic and Beyond

Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

Robertson, Luke P.; Moodie, Lindon W. K.; Holland, Darren C.; Jandér, K. Charlotte et al.

Part of Journal of Natural Products, p. 1305-1308, 2020.

DOI for Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae) Download full text (pdf) of Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

The global preclinical antibacterial pipeline

Theuretzbacher, Ursula; Outterson, Kevin; Engel, Aleks; Karlen, Anders

Part of Nature Reviews Microbiology, p. 275-285, 2020.

DOI for The global preclinical antibacterial pipeline

Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation

Chinthakindi, Praveen K.; Benediktsdottir, Andrea; Arvidsson, Per I; Chen, Yantao et al.

Part of European Journal of Organic Chemistry, p. 3796-3807, 2020.

DOI for Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation Download full text (pdf) of Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Engen, Karin; Reddy Vanga, Sudarsana; Lundbäck, Thomas; Agalo, Faith et al.

Part of ChemistryOpen, p. 325-337, 2020.

DOI for Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors Download full text (pdf) of Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Barlow, Nicholas; Reddy Vanga, Sudarsana; Sävmarker, Jonas; Sandström, Anja et al.

Part of RSC Medicinal chemistry, p. 234-244, 2020.

DOI for Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Conformational Analysis of Macrocycles: Comparing General and Specialized Methods

Olanders, Gustav; Alogheli, Hiba; Brandt, Peter; Karlén, Anders

Part of Journal of Computer-Aided Molecular Design, p. 231-252, 2020.

DOI for Conformational Analysis of Macrocycles: Comparing General and Specialized Methods Download full text (pdf) of Conformational Analysis of Macrocycles: Comparing General and Specialized Methods

High affinity rigidified AT(2) receptor ligands with indane scaffolds

Wallinder, Charlotta; Sköld, Christian; Sundholm, Sara; Guimond, Marie-Odile et al.

Part of MedChemComm, p. 2146-2160, 2019.

DOI for High affinity rigidified AT(2) receptor ligands with indane scaffolds Download full text (pdf) of High affinity rigidified AT(2) receptor ligands with indane scaffolds

Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation

Tomberg, Anna; Muratore, Michael Eric; Johansson, Magnus Jan; Terstiege, Ina et al.

Part of iScience, p. 373-+, 2019.

DOI for Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation Download full text (pdf) of Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation

Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries

Rodrigues, Leticia; Schneider, Fabian; Zhang, Xiaohan; Larsson, Elin et al.

Part of Journal of Colloid and Interface Science, p. 820-833, 2019.

DOI for Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries

Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF₃⦁SMe₂

Söderström, Marcus; Zamaratski, Edouard; Odell, Luke R.

Part of European Journal of Organic Chemistry, p. 5402-5408, 2019.

DOI for Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF₃⦁SMe₂ Download full text (pdf) of Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF₃⦁SMe₂

Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

Part of Nuclear Medicine and Biology, p. 1-10, 2019.

DOI for Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass Download full text (pdf) of Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Synthesis of Sulfonimidamide-Based Amino Acid Building Blocks with Orthogonal Protecting Groups

Chinthakindi, Praveen K.; Benediktsdottir, Andrea; Ibrahim, Ayah; Wared, Atta et al.

Part of European Journal of Organic Chemistry, p. 1045-1057, 2019.

DOI for Synthesis of Sulfonimidamide-Based Amino Acid Building Blocks with Orthogonal Protecting Groups

From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidomimetics

Hallberg, Mathias; Sandström, Anja

Part of Current protein and peptide science, p. 1038-1048, 2018.

DOI for From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidomimetics

Sulfonyl Fluorides (SFs): More Than Click Reagents?

Chinthakindi, Praveen K.; Arvidsson, Per I.

Part of European Journal of Organic Chemistry, p. 3648-3666, 2018.

DOI for Sulfonyl Fluorides (SFs): More Than Click Reagents?

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Szałaj, Natalia; Lu, Lu; Benediktsdottir, Andrea; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, p. 1346-1360, 2018.

DOI for Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 2446-2450, 2018.

DOI for An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Part of European Journal of Medicinal Chemistry, p. 453-464, 2018.

DOI for Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Part of European Journal of Pharmaceutical Sciences, p. 533-540, 2017.

DOI for Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Part of European Journal of Pharmaceutical Sciences, p. 345-351, 2017.

DOI for Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Palladium-Catalyzed Aminocarbonylation in Solid-Phase Peptide Synthesis: A Method for Capping, Cyclization, and Isotope Labeling

Skogh, Anna; Friis, Stig D.; Skrydstrup, Troels; Johansson, Anja

Part of Organic Letters, p. 2873-2876, 2017.

DOI for Palladium-Catalyzed Aminocarbonylation in Solid-Phase Peptide Synthesis: A Method for Capping, Cyclization, and Isotope Labeling

Predicting the Rate of Skin Penetration Using an Aggregated Conformal Prediction Framework

Lindh, Martin; Karlén, Anders; Norinder, Ulf

Part of Molecular Pharmaceutics, p. 1571-1576, 2017.

DOI for Predicting the Rate of Skin Penetration Using an Aggregated Conformal Prediction Framework

Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide

Alogheli, Hiba; Olanders, Gustav; Schaal, Wesley; Brandt, Peter et al.

Part of Journal of Chemical Information and Modeling, p. 190-202, 2017.

DOI for Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Part of Bioorganic & Medicinal Chemistry, p. 897-911, 2017.

DOI for Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB) Download full text (pdf) of Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

Sawant, Rajiv T.; Stevens, Marc Y.; Sköld, Christian; Odell, Luke R.

Part of Organic Letters, p. 5392-5395, 2016.

DOI for Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance

Kostyanev, T.; Bonten, M. J. M.; O'Brien, S.; Steel, H. et al.

Part of Journal of Antimicrobial Chemotherapy, p. 290-295, 2016.

DOI for The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance

Structural determinants of subtype selectivity and functional activity of angiotensin II receptors

Sallander, Jessica; Wallinder, Charlotta; Hallberg, Anders; Åqvist, Johan et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 1355-1359, 2016.

DOI for Structural determinants of subtype selectivity and functional activity of angiotensin II receptors

Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Part of Bioorganic & Medicinal Chemistry, p. 2603-2620, 2016.

DOI for Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides

Belfrage, Anna Karin; Wakchaure, Prasad; Larhed, Mats; Sandström, Anja

Part of European Journal of Organic Chemistry, p. 7069-7074, 2015.

DOI for Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides

Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Svensson, Fredrik; Engen, Karin; Lundbäck, Thomas; Larhed, Mats et al.

Part of Journal of Chemical Information and Modeling, p. 1984-1993, 2015.

DOI for Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Russo, Francesco; Gising, Johan; Åkerbladh, Linda; Roos, Annette K. et al.

Part of ChemistryOpen, p. 342-362, 2015.

DOI for Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents Download full text (pdf) of Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Borhade, Sanjay R.; Svensson, Richard; Brandt, Peter; Artursson, Per et al.

Part of ChemMedChem, p. 455-460, 2015.

DOI for Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Lindh, Martin; Svensson, Fredrik; Schaal, Wesley; Zhang, Jin et al.

Part of Journal of Chemical Information and Modeling, p. 343-353, 2015.

DOI for Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Jonsson, Anna; Fransson, Rebecca; Haramaki, Yutaka; Skogh, Anna et al.

Part of Neuroscience, p. 112-119, 2015.

DOI for Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Belfrage, Anna Karin; Gising, Johan; Svensson, Fredrik; Åkerblom, Eva et al.

Part of European Journal of Organic Chemistry, p. 978-986, 2015.

DOI for Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Synthesis of Vinyl- and Aryl–Acyl Sulfonimidamides Through Pd-Catalyzed Carbonylation Using Mo(CO)₆ as ex situ CO Source

Wakchaure, Prasad; Borhade, Sanjay; Sandström, Anja; Arvidsson, Per

Part of European Journal of Organic Chemistry, p. 213-219, 2015.

DOI for Synthesis of Vinyl- and Aryl–Acyl Sulfonimidamides Through Pd-Catalyzed Carbonylation Using Mo(CO)₆ as ex situ CO Source

Phototriggerable peptidomimetics for the inhibition of Mycobacterium turberculosis ribonucleotide reductase by targeting protein-protein binding

Karlsson, Christoffer; Blom, Magnus; Johansson, Miranda; Jansson, Anna M. et al.

Part of Organic and biomolecular chemistry, p. 2612-2621, 2015.

DOI for Phototriggerable peptidomimetics for the inhibition of Mycobacterium turberculosis ribonucleotide reductase by targeting protein-protein binding

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Wallinder, Charlotta; Sköld, Christian; Botros, Milad; Guimond, Marie-Odile et al.

Part of ACS Medicinal Chemistry Letters, p. 178-182, 2015.

DOI for Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Palladium(II) catalyzed desulfitative coupling reactions of sodium aryl sulfinates and nitriles: Scope, limitations, and mechanistic studies

Skillinghaug, Bobo; Sköld, Christian; Behrends, Malte; Sävmarker, Jonas et al.

Part of Abstracts of Papers of the American Chemical Society, 2014.

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Borhade, Sanjay R; Rosenström, Ulrika; Sävmarker, Jonas; Lundbäck, Thomas et al.

Part of ChemistryOpen, p. 256-263, 2014.

DOI for Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Skillinghaug, Bobo; Sköld, Christian; Rydfjord, Jonas; Svensson, Fredrik et al.

Part of Journal of Organic Chemistry, p. 12018-12032, 2014.

DOI for Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Part of ACS Medicinal Chemistry Letters, p. 1272-1277, 2014.

DOI for Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014.

DOI for Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Saralasin and Sarile Are AT2 Receptor Agonists

Guimond, Marie-Odile; Hallberg, Mathias; Gallo-Payet, Nicole; Wallinder, Charlotta

Part of ACS Medicinal Chemistry Letters, p. 1129-1132, 2014.

DOI for Saralasin and Sarile Are AT2 Receptor Agonists

N-terminal truncations of substance P_1-7 amide affect its action on spinal cord injury-induced mechanical allodynia in rats

Carlsson-Jonsson, Anna; Gao, Tianle; Hao, Jing-Xia; Fransson, Rebecca et al.

Part of European Journal of Pharmacology, p. 319-325, 2014.

DOI for N-terminal truncations of substance P_1-7 amide affect its action on spinal cord injury-induced mechanical allodynia in rats

Discovery and preclinical development of new antibiotics

Hughes, Diarmaid; Karlén, Anders

Part of Upsala Journal of Medical Sciences, p. 162-169, 2014.

DOI for Discovery and preclinical development of new antibiotics

N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands

Behrends, Malte; Wallinder, Charlotta; Wieckowska, Anna; Guimond, Marie-Odile et al.

Part of ChemistryOpen, p. 65-75, 2014.

DOI for N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands Download full text (pdf) of N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014.

DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands

Veron, Jean-Baptiste; Joshi, Advait; Wallinder, Charlotta; Larhed, Mats et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 476-479, 2014.

DOI for Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014.

DOI for Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Skogh, Anna; Fransson, Rebecca; Sköld, Christian; Larhed, Mats et al.

Part of Journal of Organic Chemistry, p. 12251-12256, 2013.

DOI for Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

Rydfjord, Jonas; Svensson, Fredrik; Trejos, Alejandro; Sjöberg, Per J. R. et al.

Part of Chemistry - A European Journal, p. 13803-13810, 2013.

DOI for Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

Wannberg, Johan; Wallinder, Charlotta; Unlusoy, Meltem; Sköld, Christian et al.

Part of Journal of Organic Chemistry, p. 4184-4189, 2013.

DOI for One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

Synthesis of Novel Aryl and Heteroaryl Acyl Sulfonimidamides via Pd-Catalyzed Carbonylation Using a Nongaseous Precursor

Borhade, Sanjay R.; Sandström, Anja; Arvidsson, Per I.

Part of Organic Letters, p. 1056-1059, 2013.

DOI for Synthesis of Novel Aryl and Heteroaryl Acyl Sulfonimidamides via Pd-Catalyzed Carbonylation Using a Nongaseous Precursor

DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Jansson, Anna; Więckowska, Anna; Björkelid, Christofer; Yahiaoui, Samir et al.

Part of Journal of Medicinal Chemistry, p. 6190-6199, 2013.

DOI for DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues Download full text (pdf) of DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

Svensson, Fredrik; Mane, Rajendra S.; Sävmarker, Jonas; Larhed, Mats et al.

Part of Organometallics, p. 490-497, 2013.

DOI for Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats

Shum, Michael; Pinard, Sandra; Guimond, Marie-Odile; Labbe, Sebastien M. et al.

Part of American Journal of Physiology. Endocrinology and Metabolism, p. E197-E210, 2013.

DOI for Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Part of Journal of Medicinal Chemistry, p. 4953-4965, 2013.

DOI for Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic – targeting Mycobacterium tuberculosis ribonucleotide reductase

Nurbo, Johanna; Ericsson, Daniel J.; Rosenström, Ulrika; Muthas, Daniel et al.

Part of Bioorganic & Medicinal Chemistry, p. 1992-2000, 2013.

DOI for Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic – targeting Mycobacterium tuberculosis ribonucleotide reductase

AT2 Receptor Agonists: Exploiting the Beneficial Arm of Ang II Signaling

Gallo-Payet, Nicole; Shum, Michael; Baillargeon, Jean-Patrice; Langlois, Marie-France et al.

Part of current hypertension reviews, p. 47-59, 2012.

DOI for AT2 Receptor Agonists: Exploiting the Beneficial Arm of Ang II Signaling

Comparative functional properties of two structurally similar selective nonpeptide drug-like ligands for the angiotensin II type-2 (AT2) receptor. Effects on neurite outgrowth in NG108-15 cells

Guimond, Marie-Odile; Wallinder, Charlotta; Altermann, Mathias; Hallberg, Anders et al.

Part of European Journal of Pharmacology - Molecular Pharmacology Section, p. 160-171, 2012.

DOI for Comparative functional properties of two structurally similar selective nonpeptide drug-like ligands for the angiotensin II type-2 (AT2) receptor. Effects on neurite outgrowth in NG108-15 cells

Use of Peptides as Drug Leads: A Case Story on the Development of Dipeptides Corresponding to the Heptapeptide Substance P(1-7), with Intriguing Effects on Neuropathic Pain

Fransson, Rebecca; Sandström, Anja

Part of In Neuropeptides in Neuroprotection and Neuroregeneration., p. 253-270, 2012.

DOI for Use of Peptides as Drug Leads: A Case Story on the Development of Dipeptides Corresponding to the Heptapeptide Substance P(1-7), with Intriguing Effects on Neuropathic Pain

Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Claerhout, Stijn; Sharma, Sweta; Sköld, Christian; Cavaluzzo, Claudia et al.

Part of Tetrahedron, p. 3019-3029, 2012.

DOI for Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

Sköld, Christian; Kleimark, Jonatan; Trejos, Alejandro; Odell, Luke R. et al.

Part of Chemistry - A European Journal, p. 4714-4722, 2012.

DOI for Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids Download full text (pdf) of Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

Gising, Johan; Nilsson, Mikael T; Odell, Luke R; Yahiaoui, Samir et al.

Part of Journal of Medicinal Chemistry, p. 2894-2898, 2012.

DOI for Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors Download full text (pdf) of Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

From the First Selective Non-Peptide AT(2) Receptor Agonist to Structurally Related Antagonists

Andappan, Murugaiah M. S.; Wu, Xiongyu; Wallinder, Charlotta; Mahalingam, A. K. et al.

Part of Journal of Medicinal Chemistry, p. 2265-2278, 2012.

DOI for From the First Selective Non-Peptide AT(2) Receptor Agonist to Structurally Related Antagonists

Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Svensson, Fredrik; Karlén, Anders; Sköld, Christian

Part of Journal of Chemical Information and Modeling, p. 225-232, 2012.

DOI for Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Nordqvist, Anneli; Nilsson, Mikael T.; Lagerlund, Olof; Muthas, Daniel et al.

Part of MedChemComm, p. 620-626, 2012.

DOI for Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Angiotensin II, a neuropeptide at frontier between endocrinology and neuroscience:  is there a link between the angiotensin II type 2 receptor andAlzheimer’s disease?

Gallo-Payet, Nicole; Guimond, Marie-Odile; Bilodeau, Lyne; Wallinder, Charlotta et al.

Part of Frontiers in Endocrinology, p. Article 17-, 2011.

DOI for Angiotensin II, a neuropeptide at frontier between endocrinology and neuroscience:  is there a link between the angiotensin II type 2 receptor andAlzheimer’s disease?

The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system

Ohsawa, Masahiro; Carlsson, Anna; Asato, Megumi; Koizumi, Takayuki et al.

Part of Molecular Pain, p. 85-, 2011.

DOI for The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system Download full text (pdf) of The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system

Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis

Andaloussi, Mounir; Lindh, Martin; Björkelid, Christofer; Suresh, Surisetti et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 5403-5407, 2011.

DOI for Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis

Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

Nordqvist, Anneli; Björkelid, Christofer; Andaloussi, Mounir; Jansson, Anna M. et al.

Part of Journal of Organic Chemistry, p. 8986-8998, 2011.

DOI for Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors Download full text (pdf) of Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

P2-P1 ' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Lampa, Anna; Ehrenberg, Angelica E.; Vema, Aparna; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 4917-4927, 2011.

DOI for P2-P1 ' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase

Andaloussi, Mounir; Henriksson, Lena M.; Wieckowska, Anna; Lindh, Martin et al.

Part of Journal of Medicinal Chemistry, p. 4964-4976, 2011.

DOI for Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase Download full text (pdf) of Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase

Non-peptide AT2-receptor agonists

Steckelings, U. Muscha; Larhed, Mats; Hallberg, Anders; Widdop, Robert E. et al.

Part of Current opinion in pharmacology (Print), p. 187-192, 2011.

DOI for Non-peptide AT2-receptor agonists

The effect of substance P1-7 amide on nociceptive threshold in diabetic mice

Ohsawa, Masahiro; Carlsson, Anna; Asato, Megumi; Koizumi, Takayuki et al.

Part of Peptides, p. 93-98, 2011.

DOI for The effect of substance P1-7 amide on nociceptive threshold in diabetic mice

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

Andersson, Hanna; Demaegdt, Heidi; Johnsson, Anders; Vauquelin, Georges et al.

Part of Journal of Medicinal Chemistry, p. 3779-3792, 2011.

DOI for Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

Hepatitis C protease inhibitors based on 2(1H)-pyrazinones

Gising, Johan; Belfrage, Anna Karin; Örtqvist, Pernilla; Larhed, Mats et al.

Part of Abstracts of Papers of the American Chemical Society, p. 116-MEDI-, 2010.

Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1-7

Fransson, Rebecca; Botros, Milad; Sköld, Christian; Nyberg, Fred et al.

Part of Journal of Medicinal Chemistry, p. 2383-2389, 2010.

DOI for Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1-7

Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Ax, Anna; Joshi, Advait A.; Orrling, Kristina M.; Vrang, Lotta et al.

Part of Tetrahedron, p. 4049-4056, 2010.

DOI for Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition

Mahalingam, A. K.; Wan, Yiqian; Murugaiah, A. M. S.; Wallinder, Charlotta et al.

Part of Bioorganic & Medicinal Chemistry, p. 4570-4590, 2010.

DOI for Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition

Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Örtqvist, Pernilla; Vema, Aparna; Ehrenberg, Angelica E; Dahl, Göran et al.

Part of Antiviral Therapy, p. 841-852, 2010.

DOI for Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Lampa, Anna; Ehrenberg, Angelica E.; Gustafsson, Sofia S.; Vema, Aparna et al.

Part of Bioorganic & Medicinal Chemistry, p. 5413-5424, 2010.

DOI for Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)

Andersson, Hanna; Demaegdt, Heidi; Vauquelin, Georges; Lindeberg, Gunnar et al.

Part of Journal of Medicinal Chemistry, p. 8059-8071, 2010.

DOI for Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)

Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase

Ericsson, Daniel J.; Nurbo, Johanna; Muthas, Daniel; Hertzberg, Kalle et al.

Part of Journal of Peptide Science, p. 159-164, 2010.

DOI for Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase

Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Örtqvist, Pernilla; Gising, Johan; Ehrenberg, Angelica; Vema, Aparna et al.

Part of Bioorganic & Medicinal Chemistry, p. 6512-6525, 2010.

DOI for Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Synthesis and evaluation of a ¹¹C-labelled angiotensin II AT₂ receptor ligand

Åberg, Ola; Stevens, Marc; Lindh, Jonas; Wallinder, Charlotta et al.

Part of Journal of labelled compounds & radiopharmaceuticals, p. 616-624, 2010.

DOI for Synthesis and evaluation of a ¹¹C-labelled angiotensin II AT₂ receptor ligand

Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Bergström, Christel A S; Bolin, Sara; Artursson, Per; Rönn, Robert et al.

Part of European Journal of Pharmaceutical Sciences, p. 556-563, 2009.

DOI for Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones

Gising, Johan; Örtqvist, Pernilla; Sandström, Anja; Larhed, Mats

Part of Organic and biomolecular chemistry, p. 2809-2815, 2009.

DOI for A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones

Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

Odell, Luke R.; Nilsson, Mikael T.; Gising, Johan; Lagerlund, Olof et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 4790-4793, 2009.

DOI for Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

The C-terminal amidated analogue of the Substance P (SP) fragment SP (1-7) attenuates the expression of naloxone- precipitated withdrawal in morphine dependent rats

Zhou, Qin; Carlsson, Anna; Botros, Milad; Fransson, Rebecca et al.

Part of Peptides, p. 2418-2422, 2009.

DOI for The C-terminal amidated analogue of the Substance P (SP) fragment SP (1-7) attenuates the expression of naloxone- precipitated withdrawal in morphine dependent rats

Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

Nilsson, Mikael T.; Krajewski, Wojciech W.; Srinivasa, Bachally R.; Yahiaoui, Samir et al.

Part of Journal of Molecular Biology, p. 504-513, 2009.

DOI for Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors Download full text (pdf) of Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

New developments in the discovery of agents to treat hepatitis C

Rönn, Robert; Sandström, Anja

Part of Current Topics in Medicinal Chemistry, p. 533-562, 2008.

DOI for New developments in the discovery of agents to treat hepatitis C

Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2

Andersson, Hanna; Demaegdt, Heidi; Vauquelin, Georges; Lindeberg, Gunnar et al.

Part of Bioorganic & Medicinal Chemistry, p. 6924-6935, 2008.

DOI for Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2

Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

Nordqvist, Anneli; Nilsson, Mikael T.; Röttger, Svenja; Odell, Luke R. et al.

Part of Bioorganic & Medicinal Chemistry, p. 5501-5513, 2008.

DOI for Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery Download full text (pdf) of Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering?: An investigation of the advantages and pitfalls of post-filtering

Muthas, Daniel; Sabnis, Yogesh A; Lundborg, Magnus; Karlén, Anders

Part of Journal of Molecular Graphics and Modelling, p. 1237-1251, 2008.

DOI for Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering?: An investigation of the advantages and pitfalls of post-filtering

Small peptides mimicking substance P (1-7) and encompassing a C-terminal amide functionality

Fransson, Rebecca; Botros, Milad; Nyberg, Fred; Lindeberg, Gunnar et al.

Part of Neuropeptides, p. 31-37, 2008.

DOI for Small peptides mimicking substance P (1-7) and encompassing a C-terminal amide functionality

Chemistry and folding of photomodulable peptides: stilbene and thioaurone-type candidates for conformational switches

Erdélyi, Máté; Varedian, Miranda; Sköld, Christian; Niklasson, Ida B. et al.

Part of Organic and biomolecular chemistry, p. 4356-4373, 2008.

DOI for Chemistry and folding of photomodulable peptides: stilbene and thioaurone-type candidates for conformational switches

Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening

Jacobsson, Micael; Gäredal, Magnus; Schultz, Johan; Karlén, Anders

Part of Journal of Medicinal Chemistry, p. 2777-2786, 2008.

DOI for Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening

Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships

Wallinder, Charlotta; Botros, Milad; Rosenström, Ulrika; Guimond, Marie-Odile et al.

Part of Bioorganic & Medicinal Chemistry, p. 6841-6849, 2008.

DOI for Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships

Wallinder, Charlotta

Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

2008.

Download full text (pdf) of Wallinder, Charlotta

β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors

Nurbo, Johanna; Peterson, Shane D.; Dahl, Göran; Danielson, U. Helena et al.

Part of Bioorganic & Medicinal Chemistry, p. 5590-5605, 2008.

DOI for β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors

Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Sköld, Christian; Nikiforovich, Gregory; Karlén, Anders

Part of Journal of Molecular Graphics and Modelling, p. 991-1003, 2008.

DOI for Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety

Rönn, Robert; Lampa, Anna; Peterson, Shane D.; Gossas, Thomas et al.

Part of Bioorganic & Medicinal Chemistry, p. 2955-2967, 2008.

DOI for Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

Luzhkov, Victor B.; Selisko, Barbara; Nordqvist, Anneli; Peyrane, Frédéric et al.

Part of Bioorganic & Medicinal Chemistry, p. 7795-7802, 2007.

DOI for Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3

Dahl, Göran; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

Part of Antiviral Therapy, p. 733-740, 2007.

Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3

Dahl, Göran; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

Part of The FEBS Journal, p. 5979-5986, 2007.

DOI for Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3

Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Rönn, Robert; Gossas, Thomas; Sabnis, Yogesh A.; Daoud, Hanna et al.

Part of Bioorganic & Medicinal Chemistry, p. 4057-4068, 2007.

DOI for Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3

Poliakov, Anton; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

Part of Journal of enzyme inhibition and medicinal chemistry (Print), p. 191-199, 2007.

DOI for Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3

Focused hierarchical design of peptide libraries - follow the lead

Muthas, Daniel; Lek, Per M.; Nurbo, Johanna; Karlén, Anders et al.

Part of Journal of Chemometrics, p. 486-495, 2007.

DOI for Focused hierarchical design of peptide libraries - follow the lead

Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

Lagerlund, Olof; Odell, Luke R.; Mowbray, Sherry L.; Nilsson, Mikael T. et al.

Part of Combinatorial chemistry & high throughput screening, p. 783-789, 2007.

DOI for Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach

Sunnerheim, Kerstin; Nordqvist, Anneli; Nordlander, Göran; Borg-Karlson, Anna-Karin et al.

Part of Journal of Agricultural and Food Chemistry, p. 9365-9372, 2007.

DOI for Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach

Selective angiotensin II AT(2) receptor agonists devoid of the imidazole ring system

Murugaiah, A. M. S.; Wallinder, Chalotta; Mahalingam, A. K.; Wu, Xiongyu et al.

Part of Bioorganic & Medicinal Chemistry, p. 7166-7183, 2007.

DOI for Selective angiotensin II AT(2) receptor agonists devoid of the imidazole ring system

Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor

Axén, Andreas; Andersson, Hanna; Lindeberg, Gunnar; Rönnholm, Harriet et al.

Part of Journal of Peptide Science, p. 434-444, 2007.

DOI for Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor

Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase

Nurbo, Johanna; Roos, Annette K; Muthas, Daniel; Wahlström, Erik et al.

Part of Journal of Peptide Science, p. 822-832, 2007.

DOI for Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase

Sköld, Christian

Computational Modeling of the AT₂ Receptor and AT₂ Receptor Ligands: Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models

2007.

Download full text (pdf) of Sköld, Christian

Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Georgsson, Jennie; Sköld, Christian; Botros, Milad; Lindeberg, Gunnar et al.

Part of Journal of Medicinal Chemistry, p. 1711-1715, 2007.

DOI for Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Sköld, Christian; Karlén, Anders

Part of Journal of Molecular Graphics and Modelling, p. 145-153, 2007.

DOI for Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors

Örtqvist, Pernilla; Peterson, Shane D.; Åkerblom, Eva; Gossas, Thomas et al.

Part of Bioorganic & Medicinal Chemistry, p. 1448-1474, 2007.

DOI for Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors

Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Part of Journal of Medicinal Chemistry, p. 6133-6137, 2006.

DOI for Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

Fast and selective synthesis of novel cyclic sulfamide HIV-1 purchase inhibitors under controlled microwave heating

Gold, H; Ax, A; Vrang, L; Samuelsson, B et al.

Part of Tetrahedron, p. 4671-4675, 2006.

Ligand bias of scoring functions in structure-based virtual screening.

Jacobsson, Micael; Karlén, Anders

Part of J Chem Inf Model, p. 1334-43, 2006.

Improved CoMFA modeling by optimization of settings.

Peterson, Shane D; Schaal, Wesley; Karlén, Anders

Part of J Chem Inf Model, p. 355-64, 2006.

Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies.

Skold, Christian; Winiwarter, Susanne; Wernevik, Johan; Bergstrom, Fredrik et al.

Part of J Med Chem, p. 6660-71, 2006.

Selective angiotensin II AT(2) receptor agonists: Arylbenzylimidazole structure-activity relationships

Wu, Xiongyu; Wan, Yiqian; Mahalingam, A. K.; Murugaiah, A. M. S. et al.

Part of Journal of Medicinal Chemistry, p. 7160-7168, 2006.

DOI for Selective angiotensin II AT(2) receptor agonists: Arylbenzylimidazole structure-activity relationships

Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

Rönn, Robert; Sabnis, Yogesh A; Gossas, Thomas; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 544-559, 2006.

DOI for Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

Short pseudopeptides containing turn scaffolds with high AT(2) receptor affinity

Georgsson, Jennie; Rosenström, Ulrika; Wallinder, Charlotta; Beaudry, Hélène et al.

Part of Bioorganic & Medicinal Chemistry, p. 5963-5972, 2006.

DOI for Short pseudopeptides containing turn scaffolds with high AT(2) receptor affinity

A New Structural Theme in C2-Symmetric HIV-1 Protease Inhibitors: ortho-Substituted P1/P1’ Side Chains

Wannberg, Johan; Sabnis, Yogesh A.; Vrang, Lotta; Samuelsson, Bertil et al.

Part of Bioorganic & Medicinal Chemistry, p. 5303-5315, 2006.

New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

Rosenström, Ulrika; Sköld, Christian; Plouffe, Bianca; Beaudry, Hélène et al.

Part of Journal of Medicinal Chemistry, p. 4009-4024, 2005.

DOI for New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

A new tool in peptide engineering: a photoswitchable stilbene-type beta-hairpin mimetic.

Erdélyi, Máté; Karlén, Anders; Gogoll, Adolf

Part of Chemistry, p. 403-12, 2005.

Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II.

Muthas, Daniel; Nötteberg, Daniel; Sabnis, Yogesh A; Hamelink, Elizabeth et al.

Part of Bioorg Med Chem, p. 5371-90, 2005.

Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2' to P1/P1'.

Ax, Anna; Schaal, Wesley; Vrang, Lotta; Samuelsson, Bertil et al.

Part of Bioorg Med Chem, p. 755-64, 2005.

Design, Synthesis, and Biological Evaluation of the First Selective Nonpeptide AT2 Receptor Agonist

Wan, Yigian; Wallinder, Charlotta; Plouffe, Bianca; Beaudry, Hélène et al.

Part of Journal of Medicinal Chemistry, p. 5995-6008, 2004.

DOI for Design, Synthesis, and Biological Evaluation of the First Selective Nonpeptide AT2 Receptor Agonist

First Reported Nonpeptide AT1 Receptor Agonist (L-162,313) Acts as an AT2 Receptor Agonist in Vivo

Wan, Yigian; Wallinder, Charlotta; Johansson, Berndt; Holm, Mathias et al.

Part of Journal of Medicinal Chemistry, p. 1536-1546, 2004.

DOI for First Reported Nonpeptide AT1 Receptor Agonist (L-162,313) Acts as an AT2 Receptor Agonist in Vivo

Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.

Roos, Annette K; Andersson, C Evalena; Bergfors, Terese; Jacobsson, Micael et al.

Part of J Mol Biol, p. 799-809, 2004.

AT2-selective angiotensin II analogues containing tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.

Johannesson, Petra; Erdelyi, Mate; Lindeberg, Gunnar; Frändberg, Per-Anders et al.

Part of J Med Chem, p. 6009-19, 2004.

Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors.

Afzelius, Lovisa; Zamora, Ismael; Masimirembwa, Collen M; Karlen, Anders et al.

Part of J Med Chem, p. 907-14, 2004.

Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques.

Afzelius, Lovisa; Raubacher, Florian; Karlen, Anders; Jørgensen, Flemming Steen et al.

Part of Drug Metab Dispos, p. 1218-29, 2004.

Synthesis and AT2 receptor-binding properties of angiotensin II analogues

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Part of Journal of Peptide Research, p. 194-201, 2004.

DOI for Synthesis and AT2 receptor-binding properties of angiotensin II analogues

A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Part of Journal of Medicinal Chemistry, p. 859-870, 2004.

DOI for A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Poliakov, Anton; Johansson, Anja; Åkerblom, Eva; Oscarsson, Karin et al.

Part of Biochimica et Biophysica Acta, p. 51-59, 2004.

DOI for Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-length NS3 (protease-helicase/NTPase): a comparative study of different C-terminals

Johansson, Anja; Poliakov, Anton; Åkerblom, Eva; Wiklund, Karin et al.

Part of Bioorganic & Medicinal Chemistry, p. 2551-2568, 2003.

DOI for Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-length NS3 (protease-helicase/NTPase): a comparative study of different C-terminals

Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-melphalanyl-p-L-fluorophenylalanine ethyl ester): Comparison with its m-L-sarcolysin analogue P2

Gullbo, Joachim; Wallinder, Charlotta; Tullberg, Marcus; Lövborg, Henrik et al.

Part of Molecular Cancer Therapeutics, p. 1331-1339, 2003.

Johansson, Anja

Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors

2003.

Download full text (pdf) of Johansson, Anja

Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor

Johannesson, Petra; Lindeberg, Gunnar; Johansson, Anja; Nikiforovich, Gregory V et al.

Part of Journal of Medicinal Chemistry, p. 1767-1777, 2002.

DOI for Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor

Tetrapeptides as potent protease inhibitors of Hepatitis C Virus full-length NS3 (protease-helicase/NTPase)

Johansson, Anja; Poliakov, Anton; Åkerblom, Eva; Lindeberg, Gunnar et al.

Part of Bioorganic & Medicinal Chemistry, p. 3915-22, 2002.

DOI for Tetrapeptides as potent protease inhibitors of Hepatitis C Virus full-length NS3 (protease-helicase/NTPase)

Effects of cholesterol and model transmembrane proteins on drugpartitioning into lipid bilayers as analysed by immobilized-liposomechromatography.

Lagerquist, C; Beigi, F; Karlen, A; Lennernas, H et al.

Part of J Pharm Pharmacol, p. 1477-, 2001.

Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

Johansson, Anja; Hubatsch, Ina; Åkerblom, Eva; Lindeberg, Gunnar et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 203-206, 2001.

DOI for Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen

Hämäläinen, Markku D.; Markgren, Per-Olof; Schaal, Wesley; Karlén, Anders et al.

Part of Journal of Biomolecular Screening, p. 353-359, 2000.

DOI for Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen

An Improved Procedure for N- to C-Directed (Inverse) Solid-Phase Peptide Synthesis

Johansson, Anja; Åkerblom, Eva; Ersmark, Karolina; Lindeberg, Gunnar et al.

Part of Journal of combinatorial chemistry, p. 496-507, 2000.

DOI for An Improved Procedure for N- to C-Directed (Inverse) Solid-Phase Peptide Synthesis

Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains

Hultén, Johan; Andersson, Hans O.; Schaal, Wesley; Danielson, U. Helena et al.

Part of Journal of Medicinal Chemistry, p. 4054-4061, 1999.

DOI for Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains

Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor

Bäckbro, Kristina; Löwgren, Seved; Österlund, Katrin; Atepo, Johnson et al.

Part of Journal of Medicinal Chemistry, p. 898-902, 1997.

DOI for Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor

Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol

Niklasson, Gunilla; Kvarnström, Ingemar; Classon, Björn; Samuelsson, Bertil et al.

Part of Journal of carbohydrate chemistry, p. 555-569, 1996.

DOI for Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol