Pharmacognosy
Research in pharmacognosy is focused on bioactive substances of natural origin. We develop strategies for selection, isolation and characterisation with the objective to discover unique bioactive chemical structures with drug potential, and to reveal unknown targets, by studying the evolutionary structure-activity optimization in Nature.
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Fieldwork: truffle hunting -
Isolation of cyclic peptides from plants -
Fieldwork: sponge collecting -
A deep-sea sponge crude extract with some antibacterial activity -
Extracting RNA from marine worms for transcriptomics -
Exploring the chemical space to select and predict new drug leads -
Growing and collecting violet leaves for peptide extractions -
Setting up a Leishmania assay -
Designing grafted peptides as new drug leads -
Extracting sponge DNA with magnetic beads
Research focus
In addition to the possibility to discover new drug candidates for drug development, bioactive natural products have potential as pharmacological tools, intermediates, or templates for synthesis of drugs. As a multidisciplinary division we conduct extensive national and international research collaborations in e.g. clinical pharmacology, marine chemical ecology, systematic botany and structural biology.
Our research represents a modernization and renewal of a venerable proven science, Pharmacognosy. With today's increased interest for environmental aspects, green chemistry, and a sustainable use of natural products, this renewal could have a strategic position in bridging chemistry and biology.
The ongoing projects are focused on chemistry and biology of ultra stable proteins, methods of selection and target-finding, antifouling and antibacterial molecules from marine organisms (sponges, nemertines), anti-inflammatory and antitumor activity of natural products.
The Pharmacognosy Research Group, BMC December 2015.
News Pharmacognosy
- April 2020. Paco Cárdenas has been awarded SciLifeLab Bioinformatics Long-term Support
- Synthetic compound masquerading as natural product? Article in focus by Luke Robertson et al.
- In the top 100 of articles in the largest scientific journal in the world
- Hesham El Seedi takes part in the celebration of Vivi Täckholm in Cairo
- 21 December 2018. Old Chemistry Springs into Life - Scientific Breakthrough of the Year!
Contacts
We are constantly looking for MSc students. Contact Prof. Ulf Göransson to know more, or browse our group pages.
Are you a student at the Faculty of Pharmacy, do not forget that you can apply to the Summer research school SOFOSKO!
Publications
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A community assessment of the demersal fish and benthic invertebrates of the Rosemary Bank Seamount marine protected area (NE Atlantic)
2020
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A newly isolated strain of Halomonas sp. (HA1) exerts anticancer potential via induction of apoptosis and G(2)/M arrest in hepatocellular carcinoma (HepG2) cell line
2020
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Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents
2020
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Apitoxin and Its Components against Cancer, Neurodegeneration and Rheumatoid Arthritis: Limitations and Possibilities
2020
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Authentication of the geographical origin of Roselle (Hibiscus sabdariffa L) using various spectroscopies: NIR, low-field NMR and fluorescence
2020
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Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
2020
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Behavioral and physiological effects of Viola spp. cyclotides on Myzus persicae (Sulz.)
2020
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Biological and conventional food processing modifications on food proteins: Structure, functionality, and bioactivity
2020
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Chemometrics coupled 4-Aminothiophenol labelled Ag-Au alloy SERS off-signal nanosensor for quantitative detection of mercury in black tea
2020
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Classification for Penicillium expansum Spoilage and Defect in Apples by Electronic Nose Combined with Chemometrics
2020
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Developmental toxicity of carbon nanoparticles during embryogenesis in chicken
2020
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Effect of Thermal Cycling on Flexural Properties of Microcrystalline Cellulose-Reinforced Denture Base Acrylic Resins
2020
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Emerging Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer's Disease
2020
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Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects
2020
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Evaluating Antimycobacterial Screening Schemes Using Chemical Global Positioning System-Natural Product Analysis
2020
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Exploring evolutionary and chemical space using chemoinformatic tools and traditional methods in pharmacognosy
2020
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Historical Continuity or Different Sensory Worlds?: What we Can Learn about the Sensory Characteristics of Early Modern Pharmaceuticals by Taking Them to a Trained Sensory Panel.
2020
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Honeybee products: An updated review of neurological actions
2020
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In Vitro Antigenotoxic, Antihelminthic and Antioxidant Potentials Based on the Extracted Metabolites from Lichen,Candelariella vitellina
2020
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Insights into the symbiotic relationship between scale worms and carnivorous sponges (Cladorhizidae, Chondrocladia)
2020
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Moringa oleifera leaves extract enhances fresh and cryopreserved semen characters of Barki rams
2020
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New Rare Ent-Clerodane Diterpene Peroxides from Egyptian Mountain Tea (Qourtom) and Its Chemosystem as Herbal Remedies and Phytonutrients Agents
2020
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Nondestructive monitoring storage quality of apples at different temperatures by near-infrared transmittance spectroscopy
2020
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Novel Insight into Utilization of Flavonoid Glycosides and Biological Properties of Saffron (Crocus sativus L.) Flower Byproducts
2020
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Novel N-(benzo[d]oxazol-2-yl)alkanamides: synthesis and carbonic anhydrase II inhibition studies
2020
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One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents
2020
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Pharmacokinetics and Transport of an Osteogenic Dodecapeptide
2020
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Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity
2020
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Quantitative detection of apple watercore and soluble solids content by near infrared transmittance spectroscopy
2020
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Recent insights into chemical and pharmacological studies of bee bread
2020
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Revisiting the Amyloid Cascade Hypothesis: From Anti-A beta Therapeutics to Auspicious New Ways for Alzheimer's Disease
2020
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Rock sponges (lithistid Demospongiae) of the Northeast Atlantic seamounts, with description of ten new species
2020
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Sex, Molecules, and Gene control: Ecophysiological and evolutionary aspects of key sponge species from Antarctic shallow waters and the deep sea
2020
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Simultaneous quantification of active constituents and antioxidant capability of green tea using NIR spectroscopy coupled with swarm intelligence algorithm
2020
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Sources of C30 steroid biomarkers in Neoproterozoic-Cambrian rocks and oils
2020
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Structure and Chemical Analysis of Major Specialized Metabolites Produced by the Lichen Evernia prunastri
2020
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Sturgeon hydrolysates alleviate DSS-induced colon colitis in mice by modulating NF-kappa B, MAPK, and microbiota composition
2020
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Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)
2020
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Supplementary files to Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum: a histological, lipidomic and transcriptomic approach, Manuscript IV, Thesis
2020
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The Many Faces of Kefir Fermented Dairy Products: Quality Characteristics, Flavour Chemistry, Nutritional Value, Health Benefits, and Safety
2020
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The Molecular Machinery of Gametogenesis in Geodia Demosponges (Porifera): Evolutionary Origins of a Conserved Toolkit across Animals
2020
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A green synthetic approach using chili plant supported Ag/Ag2O@P25 heterostructure with enhanced photocatalytic properties under solar irradiation
2019
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A new deep-water Tethya (Porifera, Tethyida, Tethyidae) from the Great Australian Bight and an updated Tethyida phylogeny
2019
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A review on advanced microencapsulation technology to enhance bioavailability of phenolic compounds: Based on its activity in the treatment of Type 2 Diabetes
2019
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Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities
2019
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Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice
2019
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Biogenesis of ZnO nanoparticles using Pandanus odorifer leaf extract: anticancer and antimicrobial activities
2019
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Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts
2019
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Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions
2019
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Cardenolides: Insights from chemical structure and pharmacological utility
2019