Biomarker Discovery - Globisch Lab

Chemical Biology, Organic Chemistry, METABOLOMICS, and Mass Spectrometry

The Globisch lab is an international research group with focus on the development of new Chemical Biology-based methodologies to improve the analysis of small molecule metabolites in biological samples. These new methodologies are aimed at enhancing the scope of metabolomics-based research. In our multidisciplinary research we work at the interface of Chemistry and Biology with a combination of Organic Chemistry, Chemical Biology techniques, Biochemistry, mass spectrometric analysis of metabolites, and metabolomics. The discovery of specific early-stage biomarkers, new drug targets and the development of new therapeutic interventions are crucial for disease prevention and management towards personalized medicine.

Biomarker Discovery is a challenging and multidisciplinary task. We develop new tools for mass spectrometric analysis and are focussed on elucidating microbiota metabolism. We investigate any human sample type, e.g. fecal, urine, and plasma samples from pancreatic cancer patients.

Main research projects:

1) Synthesis and application of unique and multifunctional chemoselective probes

Chemoselective Probe Image

2) Investigation of microbiota and human host co-metabolism

Microbiome Metabolism Image

3) Global Metabolomics analysis

Image of the Global Metabolomics workflow

4) Chemical synthesis of metabolites for quantification and structure elucidation

Chemical synthesis scheme

Funding agencies:

Logo of Science For Laboratory Logo of VR Logo of Cancerfonden
Logo of Hjärnfonden Logo of Carl Tryggers Stipendiestiftelse

We also appreciate funding from The National Molecular Medicine Fellows Program (NMMP)