Publikationer

Green multifunctional palladium nanoparticles from polysaccharide cordia myxa (CMY) gum: Synthesis, characterization, and antibacterial activity

Nagaraja, Kasula; Bagineni, Prasad; Almarhoon, Zainab M.; Oh, Tae Hwan

Ingår i Colloids and Surfaces A, 2023.

DOI för Green multifunctional palladium nanoparticles from polysaccharide cordia myxa (CMY) gum: Synthesis, characterization, and antibacterial activity

Söderström, Marcus

C1 Building Blocks: New Approaches for Thiomethylations and Esterification

A1:111a, BMC, Husargatan 3, Uppsala 2023-12-20 kl 13:15

Ladda ner fulltext (pdf) av Söderström, Marcus

Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF₃SMe₂

Söderström, Marcus; Matt, Christof; Odell, Luke R.

Ingår i ACS Omega, s. 4320-4330, 2023.

DOI för Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF₃SMe₂ Ladda ner fulltext (pdf) av Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF₃SMe₂

Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH

Das, Biswanath; Toledo-Carrillo, Esteban A.; Li, Guoqi; Stahle, Jonas et al.

Ingår i Journal of Materials Chemistry A, s. 13331-13340, 2023.

DOI för Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH Ladda ner fulltext (pdf) av Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH

A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane

Schembri, Luke S; Olaniran, Esther; Söderström, Marcus; Skillinghaug, Bobo et al.

Ingår i Advanced Synthesis and Catalysis, s. 1839-1845, 2023.

DOI för A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane Ladda ner fulltext (pdf) av A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane

Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents

Craig, Alexander J.; Ermolovich, Yuri; Cameron, Alan; Rodler, Agnes et al.

Ingår i ACS Medicinal Chemistry Letters, s. 802-809, 2023.

DOI för Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents

Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Caldeweyher, Eike; Elkin, Masha; Gheibi, Golsa; Johansson, Magnus et al.

Ingår i Journal of the American Chemical Society, s. 17367-17376, 2023.

DOI för Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Characterization of a Newly Available Coastal Marine Dissolved Organic Matter Reference Material (TRM-0522)

Felgate, Stacey; Craig, Alexander J.; Moodie, Lindon W. K.; Hawkes, Jeffrey A.

Ingår i Analytical Chemistry, s. 6559-6567, 2023.

DOI för Characterization of a Newly Available Coastal Marine Dissolved Organic Matter Reference Material (TRM-0522) Ladda ner fulltext (pdf) av Characterization of a Newly Available Coastal Marine Dissolved Organic Matter Reference Material (TRM-0522)

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Ingår i Scientific Reports, 2023.

DOI för Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma Ladda ner fulltext (pdf) av Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

Tannergren, Christer; Jadhav, Harshad; Eckernas, Emma; Fagerberg, Jonas et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 144-159, 2023.

DOI för Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging

Kaya, Ibrahim; Schembri, Luke S; Nilsson, Anna; Shariatgorji, Reza et al.

Ingår i Journal of the American Society for Mass Spectrometry, s. 836-846, 2023.

DOI för On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging Ladda ner fulltext (pdf) av On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging

Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

Garcia, Mauricio A.; Hensler, Gonul; Al-Gousous, Jozef; Pielenhofer, Jonas et al.

Ingår i Drug Metabolism and Pharmacokinetics, 2023.

DOI för Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

SPICY: a method for single scan rotating frame relaxometry

Tolkkinen, Katja; Mailhiot, Sarah; Selent, Anne; Mankinen, Otto et al.

Ingår i Physical Chemistry, Chemical Physics - PCCP, s. 13164-13169, 2023.

DOI för SPICY: a method for single scan rotating frame relaxometry Ladda ner fulltext (pdf) av SPICY: a method for single scan rotating frame relaxometry

[¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44

Cheung, Pierre; Amin, Mohammad A.; Zhang, Bo; Lechi, Francesco et al.

Ingår i Pharmaceutics, 2023.

DOI för [¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 Ladda ner fulltext (pdf) av [¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44

Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols

Zhang, Jianwei; Das, Biswanath; Verho, Oscar; Bäckvall, Jan-E.

Ingår i Angewandte Chemie International Edition, 2022.

DOI för Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols Ladda ner fulltext (pdf) av Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols

Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation

Das, Biswanath; Toledo-Carrillo, Esteban Alejandro; Li, Lin; Ye, Fei et al.

Ingår i ChemCatChem, 2022.

DOI för Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation

Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule

Grinkevich, Vera V.; Vema, Aparna; Fawkner, Karin; Issaeva, Natalia et al.

Ingår i Frontiers in Molecular Biosciences, 2022.

DOI för Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule Ladda ner fulltext (pdf) av Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule

Bacterial type I signal peptidase inhibitors-Optimized hits from nature

Szalaj, Natalia; Benediktsdottir, Andrea; Rusin, Dominika; Karlén, Anders et al.

Ingår i European Journal of Medicinal Chemistry, 2022.

DOI för Bacterial type I signal peptidase inhibitors-Optimized hits from nature

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Roy, Tamal; Petersen, Nadia N.; Gopalan, Greeshma; Gising, Johan et al.

Ingår i Bioorganic & Medicinal Chemistry, 2022.

DOI för 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands Ladda ner fulltext (pdf) av 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Ingår i International Journal of Molecular Sciences, 2022.

DOI för Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats Ladda ner fulltext (pdf) av Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Ingår i Journal of the American Chemical Society, s. 2905-2920, 2022.

DOI för Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses Ladda ner fulltext (pdf) av Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Dipolar Relaxation of Water Protons in the Vicinity of a Collagen-like Peptide

Karjalainen, Jouni; Henschel, Henning; Nissi, Mikko J.; Nieminen, Miika T. et al.

Ingår i Journal of Physical Chemistry B, s. 2538-2551, 2022.

DOI för Dipolar Relaxation of Water Protons in the Vicinity of a Collagen-like Peptide Ladda ner fulltext (pdf) av Dipolar Relaxation of Water Protons in the Vicinity of a Collagen-like Peptide

Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Safa, Neda; Trobec, Tomaz.; Holland, Darren C.; Slazak, Blazej et al.

Ingår i Journal of Natural Products, s. 215-224, 2022.

DOI för Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum Ladda ner fulltext (pdf) av Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Ingår i International Journal of Molecular Sciences, 2022.

DOI för Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats Ladda ner fulltext (pdf) av Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Ingår i Cells, 2022.

DOI för Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Ladda ner fulltext (pdf) av Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Brem, Jürgen; Panduwawala, Tharindi; Hansen, Jon Ulf; Hewitt, Joanne et al.

Ingår i Nature Chemistry, s. 15-24, 2022.

DOI för Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Ingår i ACS Infectious Diseases, s. 482-498, 2022.

DOI för Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2) Ladda ner fulltext (pdf) av Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Towards the sustainable discovery and development of new antibiotics

Miethke, Marcus; Pieroni, Marco; Weber, Tilmann; Brönstrup, Mark et al.

Ingår i Nature Reviews Chemistry, s. 726-749, 2021.

DOI för Towards the sustainable discovery and development of new antibiotics

A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Meineke, Birthe; Heimgärtner, Johannes; Craig, Alexander J.; Landreh, Michael et al.

Ingår i Frontiers in Chemistry, 2021.

DOI för A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling Ladda ner fulltext (pdf) av A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies

Mouhib, Mohammed; Benediktsdottir, Andrea; Svensson Nilsson, Caroline; Chi, Celestine N.

Ingår i ACS Omega, s. 24377-24381, 2021.

DOI för Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies Ladda ner fulltext (pdf) av Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies

The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation

Das, Biswanath; Rahaman, Ahibur; Shatskiy, Andrey; Verho, Oscar et al.

Ingår i Accounts of Chemical Research, s. 3326-3337, 2021.

DOI för The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation Ladda ner fulltext (pdf) av The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation

Organic reactivity from mechanism to machine learning

Jorner, Kjell; Tomberg, Anna; Bauer, Christoph; Sköld, Christian et al.

Ingår i Nature Reviews Chemistry, s. 240-255, 2021.

DOI för Organic reactivity from mechanism to machine learning

Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors

Akaberi, Dario; Bahlstrom, Amanda; Chinthakindi, Praveen K.; Nyman, Tomas et al.

Ingår i Antiviral Research, 2021.

DOI för Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors

A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal

Lati, Monireh Pourghasemi; Stahle, Jonas; Meyer, Michael; Verho, Oscar

Ingår i Journal of Organic Chemistry, s. 8527-8537, 2021.

DOI för A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal Ladda ner fulltext (pdf) av A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal

Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Benediktsdottir, Andrea; Lu, Lu; Cao, Sha; Zamaratski, Edouard et al.

Ingår i European Journal of Medicinal Chemistry, 2021.

DOI för Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation Ladda ner fulltext (pdf) av Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

ENABLE: an engine for European antibacterial drug discovery and development

Olliver, Marie; Griestop, Laura; Hughes, Diarmaid; Belfrage, Anna Karin et al.

Ingår i Nature reviews. Drug discovery, s. 407-408, 2021.

DOI för ENABLE: an engine for European antibacterial drug discovery and development

Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Olanders, Gustav; Brandt, Peter; Sköld, Christian; Karlen, Anders

Ingår i Bioorganic & Medicinal Chemistry, 2021.

DOI för Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs Ladda ner fulltext (pdf) av Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS

Yuan, Ning; Gudmundsson, Arnar; Gustafson, Karl P. J.; Oschmann, Michael et al.

Ingår i ACS Catalysis, s. 2999-3008, 2021.

DOI för Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS Ladda ner fulltext (pdf) av Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS

Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

Byrne, Liam; Sköld, Christian; Norrby, Per-Ola; Munday, Rachel H. et al.

Ingår i Advanced Synthesis and Catalysis, s. 259-267, 2021.

DOI för Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

Nyman, Julia; Guo, Ning; Sandström, Anja; Hallberg, Mathias et al.

Ingår i European Journal of Pharmacology, 2021.

DOI för The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

Carlström, Karl E.; Chinthakindi, Praveen K.; Espinosa, Belen; Al Nimer, Faiez et al.

Ingår i NEUROTHERAPEUTICS, s. 1142-1152, 2020.

DOI för Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate Ladda ner fulltext (pdf) av Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

Nanocatalysis Meets Biology

Verho, Oscar; Backvall, Jan-E.

Ingår i Nanoparticles in catalysis, s. 243-278, 2020.

DOI för Nanocatalysis Meets Biology

Phidianidine A and Synthetic Analogues as Naturally Inspired Marine Antifoulants

Labriere, Christophe; Elumalai, Vijayaragavan; Staffansson, Jannie; Cervin, Gunnar et al.

Ingår i Journal of Natural Products, s. 3413-3423, 2020.

DOI för Phidianidine A and Synthetic Analogues as Naturally Inspired Marine Antifoulants

Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease

Akaberi, Dario; Chinthakindi, Praveen K.; Båhlström, Amanda; Palanisamy, Navaneethan et al.

Ingår i Journal of Biomolecular Structure and Dynamics, s. 5526-5536, 2020.

DOI för Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease Ladda ner fulltext (pdf) av Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease

Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Ingår i ADMET & DMPK, s. 375-390, 2020.

DOI för Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models Ladda ner fulltext (pdf) av Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Turning Information Dissipation into Dissemination: Instagram as a Communication Enhancing Tool during the COVID-19 Pandemic and Beyond

Ye, Sofie; Hartmann, Rafael; Söderström, Marcus; Amin, Mohammad A. et al.

Ingår i Journal of Chemical Education, s. 3217-3222, 2020.

DOI för Turning Information Dissipation into Dissemination: Instagram as a Communication Enhancing Tool during the COVID-19 Pandemic and Beyond

Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

Robertson, Luke P.; Moodie, Lindon W. K.; Holland, Darren C.; Jandér, K. Charlotte et al.

Ingår i Journal of Natural Products, s. 1305-1308, 2020.

DOI för Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae) Ladda ner fulltext (pdf) av Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

The global preclinical antibacterial pipeline

Theuretzbacher, Ursula; Outterson, Kevin; Engel, Aleks; Karlen, Anders

Ingår i Nature Reviews Microbiology, s. 275-285, 2020.

DOI för The global preclinical antibacterial pipeline

Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation

Chinthakindi, Praveen K.; Benediktsdottir, Andrea; Arvidsson, Per I; Chen, Yantao et al.

Ingår i European Journal of Organic Chemistry, s. 3796-3807, 2020.

DOI för Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation Ladda ner fulltext (pdf) av Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Engen, Karin; Reddy Vanga, Sudarsana; Lundbäck, Thomas; Agalo, Faith et al.

Ingår i ChemistryOpen, s. 325-337, 2020.

DOI för Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors Ladda ner fulltext (pdf) av Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Barlow, Nicholas; Reddy Vanga, Sudarsana; Sävmarker, Jonas; Sandström, Anja et al.

Ingår i RSC Medicinal chemistry, s. 234-244, 2020.

DOI för Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Conformational Analysis of Macrocycles: Comparing General and Specialized Methods

Olanders, Gustav; Alogheli, Hiba; Brandt, Peter; Karlén, Anders

Ingår i Journal of Computer-Aided Molecular Design, s. 231-252, 2020.

DOI för Conformational Analysis of Macrocycles: Comparing General and Specialized Methods Ladda ner fulltext (pdf) av Conformational Analysis of Macrocycles: Comparing General and Specialized Methods

High affinity rigidified AT(2) receptor ligands with indane scaffolds

Wallinder, Charlotta; Sköld, Christian; Sundholm, Sara; Guimond, Marie-Odile et al.

Ingår i MedChemComm, s. 2146-2160, 2019.

DOI för High affinity rigidified AT(2) receptor ligands with indane scaffolds Ladda ner fulltext (pdf) av High affinity rigidified AT(2) receptor ligands with indane scaffolds

Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation

Tomberg, Anna; Muratore, Michael Eric; Johansson, Magnus Jan; Terstiege, Ina et al.

Ingår i iScience, s. 373-+, 2019.

DOI för Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation Ladda ner fulltext (pdf) av Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation

Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries

Rodrigues, Leticia; Schneider, Fabian; Zhang, Xiaohan; Larsson, Elin et al.

Ingår i Journal of Colloid and Interface Science, s. 820-833, 2019.

DOI för Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries

Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF₃⦁SMe₂

Söderström, Marcus; Zamaratski, Edouard; Odell, Luke R.

Ingår i European Journal of Organic Chemistry, s. 5402-5408, 2019.

DOI för Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF₃⦁SMe₂ Ladda ner fulltext (pdf) av Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF₃⦁SMe₂

Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

Ingår i Nuclear Medicine and Biology, s. 1-10, 2019.

DOI för Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass Ladda ner fulltext (pdf) av Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Synthesis of Sulfonimidamide-Based Amino Acid Building Blocks with Orthogonal Protecting Groups

Chinthakindi, Praveen K.; Benediktsdottir, Andrea; Ibrahim, Ayah; Wared, Atta et al.

Ingår i European Journal of Organic Chemistry, s. 1045-1057, 2019.

DOI för Synthesis of Sulfonimidamide-Based Amino Acid Building Blocks with Orthogonal Protecting Groups

From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidomimetics

Hallberg, Mathias; Sandström, Anja

Ingår i Current protein and peptide science, s. 1038-1048, 2018.

DOI för From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidomimetics

Sulfonyl Fluorides (SFs): More Than Click Reagents?

Chinthakindi, Praveen K.; Arvidsson, Per I.

Ingår i European Journal of Organic Chemistry, s. 3648-3666, 2018.

DOI för Sulfonyl Fluorides (SFs): More Than Click Reagents?

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Szałaj, Natalia; Lu, Lu; Benediktsdottir, Andrea; Zamaratski, Edouard et al.

Ingår i European Journal of Medicinal Chemistry, s. 1346-1360, 2018.

DOI för Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 2446-2450, 2018.

DOI för An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Ingår i European Journal of Medicinal Chemistry, s. 453-464, 2018.

DOI för Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 533-540, 2017.

DOI för Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 345-351, 2017.

DOI för Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Palladium-Catalyzed Aminocarbonylation in Solid-Phase Peptide Synthesis: A Method for Capping, Cyclization, and Isotope Labeling

Skogh, Anna; Friis, Stig D.; Skrydstrup, Troels; Johansson, Anja

Ingår i Organic Letters, s. 2873-2876, 2017.

DOI för Palladium-Catalyzed Aminocarbonylation in Solid-Phase Peptide Synthesis: A Method for Capping, Cyclization, and Isotope Labeling

Predicting the Rate of Skin Penetration Using an Aggregated Conformal Prediction Framework

Lindh, Martin; Karlén, Anders; Norinder, Ulf

Ingår i Molecular Pharmaceutics, s. 1571-1576, 2017.

DOI för Predicting the Rate of Skin Penetration Using an Aggregated Conformal Prediction Framework

Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide

Alogheli, Hiba; Olanders, Gustav; Schaal, Wesley; Brandt, Peter et al.

Ingår i Journal of Chemical Information and Modeling, s. 190-202, 2017.

DOI för Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 897-911, 2017.

DOI för Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB) Ladda ner fulltext (pdf) av Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

Sawant, Rajiv T.; Stevens, Marc Y.; Sköld, Christian; Odell, Luke R.

Ingår i Organic Letters, s. 5392-5395, 2016.

DOI för Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance

Kostyanev, T.; Bonten, M. J. M.; O'Brien, S.; Steel, H. et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 290-295, 2016.

DOI för The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance

Structural determinants of subtype selectivity and functional activity of angiotensin II receptors

Sallander, Jessica; Wallinder, Charlotta; Hallberg, Anders; Åqvist, Johan et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 1355-1359, 2016.

DOI för Structural determinants of subtype selectivity and functional activity of angiotensin II receptors

Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 2603-2620, 2016.

DOI för Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides

Belfrage, Anna Karin; Wakchaure, Prasad; Larhed, Mats; Sandström, Anja

Ingår i European Journal of Organic Chemistry, s. 7069-7074, 2015.

DOI för Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides

Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Svensson, Fredrik; Engen, Karin; Lundbäck, Thomas; Larhed, Mats et al.

Ingår i Journal of Chemical Information and Modeling, s. 1984-1993, 2015.

DOI för Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Russo, Francesco; Gising, Johan; Åkerbladh, Linda; Roos, Annette K. et al.

Ingår i ChemistryOpen, s. 342-362, 2015.

DOI för Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents Ladda ner fulltext (pdf) av Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Borhade, Sanjay R.; Svensson, Richard; Brandt, Peter; Artursson, Per et al.

Ingår i ChemMedChem, s. 455-460, 2015.

DOI för Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Lindh, Martin; Svensson, Fredrik; Schaal, Wesley; Zhang, Jin et al.

Ingår i Journal of Chemical Information and Modeling, s. 343-353, 2015.

DOI för Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Jonsson, Anna; Fransson, Rebecca; Haramaki, Yutaka; Skogh, Anna et al.

Ingår i Neuroscience, s. 112-119, 2015.

DOI för Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Belfrage, Anna Karin; Gising, Johan; Svensson, Fredrik; Åkerblom, Eva et al.

Ingår i European Journal of Organic Chemistry, s. 978-986, 2015.

DOI för Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Synthesis of Vinyl- and Aryl–Acyl Sulfonimidamides Through Pd-Catalyzed Carbonylation Using Mo(CO)₆ as ex situ CO Source

Wakchaure, Prasad; Borhade, Sanjay; Sandström, Anja; Arvidsson, Per

Ingår i European Journal of Organic Chemistry, s. 213-219, 2015.

DOI för Synthesis of Vinyl- and Aryl–Acyl Sulfonimidamides Through Pd-Catalyzed Carbonylation Using Mo(CO)₆ as ex situ CO Source

Phototriggerable peptidomimetics for the inhibition of Mycobacterium turberculosis ribonucleotide reductase by targeting protein-protein binding

Karlsson, Christoffer; Blom, Magnus; Johansson, Miranda; Jansson, Anna M. et al.

Ingår i Organic and biomolecular chemistry, s. 2612-2621, 2015.

DOI för Phototriggerable peptidomimetics for the inhibition of Mycobacterium turberculosis ribonucleotide reductase by targeting protein-protein binding

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Wallinder, Charlotta; Sköld, Christian; Botros, Milad; Guimond, Marie-Odile et al.

Ingår i ACS Medicinal Chemistry Letters, s. 178-182, 2015.

DOI för Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Palladium(II) catalyzed desulfitative coupling reactions of sodium aryl sulfinates and nitriles: Scope, limitations, and mechanistic studies

Skillinghaug, Bobo; Sköld, Christian; Behrends, Malte; Sävmarker, Jonas et al.

Ingår i Abstracts of Papers of the American Chemical Society, 2014.

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Borhade, Sanjay R; Rosenström, Ulrika; Sävmarker, Jonas; Lundbäck, Thomas et al.

Ingår i ChemistryOpen, s. 256-263, 2014.

DOI för Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Skillinghaug, Bobo; Sköld, Christian; Rydfjord, Jonas; Svensson, Fredrik et al.

Ingår i Journal of Organic Chemistry, s. 12018-12032, 2014.

DOI för Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Ingår i ACS Medicinal Chemistry Letters, s. 1272-1277, 2014.

DOI för Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6595-6615, 2014.

DOI för Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Saralasin and Sarile Are AT2 Receptor Agonists

Guimond, Marie-Odile; Hallberg, Mathias; Gallo-Payet, Nicole; Wallinder, Charlotta

Ingår i ACS Medicinal Chemistry Letters, s. 1129-1132, 2014.

DOI för Saralasin and Sarile Are AT2 Receptor Agonists

N-terminal truncations of substance P_1-7 amide affect its action on spinal cord injury-induced mechanical allodynia in rats

Carlsson-Jonsson, Anna; Gao, Tianle; Hao, Jing-Xia; Fransson, Rebecca et al.

Ingår i European Journal of Pharmacology, s. 319-325, 2014.

DOI för N-terminal truncations of substance P_1-7 amide affect its action on spinal cord injury-induced mechanical allodynia in rats

Discovery and preclinical development of new antibiotics

Hughes, Diarmaid; Karlén, Anders

Ingår i Upsala Journal of Medical Sciences, s. 162-169, 2014.

DOI för Discovery and preclinical development of new antibiotics

N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands

Behrends, Malte; Wallinder, Charlotta; Wieckowska, Anna; Guimond, Marie-Odile et al.

Ingår i ChemistryOpen, s. 65-75, 2014.

DOI för N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands Ladda ner fulltext (pdf) av N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Ingår i ACS Medicinal Chemistry Letters, s. 249-254, 2014.

DOI för Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands

Veron, Jean-Baptiste; Joshi, Advait; Wallinder, Charlotta; Larhed, Mats et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 476-479, 2014.

DOI för Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Ingår i Journal of Medicinal Chemistry, s. 1790-1801, 2014.

DOI för Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Skogh, Anna; Fransson, Rebecca; Sköld, Christian; Larhed, Mats et al.

Ingår i Journal of Organic Chemistry, s. 12251-12256, 2013.

DOI för Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

Rydfjord, Jonas; Svensson, Fredrik; Trejos, Alejandro; Sjöberg, Per J. R. et al.

Ingår i Chemistry - A European Journal, s. 13803-13810, 2013.

DOI för Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

Wannberg, Johan; Wallinder, Charlotta; Unlusoy, Meltem; Sköld, Christian et al.

Ingår i Journal of Organic Chemistry, s. 4184-4189, 2013.

DOI för One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

Synthesis of Novel Aryl and Heteroaryl Acyl Sulfonimidamides via Pd-Catalyzed Carbonylation Using a Nongaseous Precursor

Borhade, Sanjay R.; Sandström, Anja; Arvidsson, Per I.

Ingår i Organic Letters, s. 1056-1059, 2013.

DOI för Synthesis of Novel Aryl and Heteroaryl Acyl Sulfonimidamides via Pd-Catalyzed Carbonylation Using a Nongaseous Precursor

DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Jansson, Anna; Więckowska, Anna; Björkelid, Christofer; Yahiaoui, Samir et al.

Ingår i Journal of Medicinal Chemistry, s. 6190-6199, 2013.

DOI för DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues Ladda ner fulltext (pdf) av DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

Svensson, Fredrik; Mane, Rajendra S.; Sävmarker, Jonas; Larhed, Mats et al.

Ingår i Organometallics, s. 490-497, 2013.

DOI för Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats

Shum, Michael; Pinard, Sandra; Guimond, Marie-Odile; Labbe, Sebastien M. et al.

Ingår i American Journal of Physiology. Endocrinology and Metabolism, s. E197-E210, 2013.

DOI för Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Ingår i Journal of Medicinal Chemistry, s. 4953-4965, 2013.

DOI för Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic – targeting Mycobacterium tuberculosis ribonucleotide reductase

Nurbo, Johanna; Ericsson, Daniel J.; Rosenström, Ulrika; Muthas, Daniel et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 1992-2000, 2013.

DOI för Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic – targeting Mycobacterium tuberculosis ribonucleotide reductase

AT2 Receptor Agonists: Exploiting the Beneficial Arm of Ang II Signaling

Gallo-Payet, Nicole; Shum, Michael; Baillargeon, Jean-Patrice; Langlois, Marie-France et al.

Ingår i current hypertension reviews, s. 47-59, 2012.

DOI för AT2 Receptor Agonists: Exploiting the Beneficial Arm of Ang II Signaling

Comparative functional properties of two structurally similar selective nonpeptide drug-like ligands for the angiotensin II type-2 (AT2) receptor. Effects on neurite outgrowth in NG108-15 cells

Guimond, Marie-Odile; Wallinder, Charlotta; Altermann, Mathias; Hallberg, Anders et al.

Ingår i European Journal of Pharmacology - Molecular Pharmacology Section, s. 160-171, 2012.

DOI för Comparative functional properties of two structurally similar selective nonpeptide drug-like ligands for the angiotensin II type-2 (AT2) receptor. Effects on neurite outgrowth in NG108-15 cells

Use of Peptides as Drug Leads: A Case Story on the Development of Dipeptides Corresponding to the Heptapeptide Substance P(1-7), with Intriguing Effects on Neuropathic Pain

Fransson, Rebecca; Sandström, Anja

Ingår i In Neuropeptides in Neuroprotection and Neuroregeneration., s. 253-270, 2012.

DOI för Use of Peptides as Drug Leads: A Case Story on the Development of Dipeptides Corresponding to the Heptapeptide Substance P(1-7), with Intriguing Effects on Neuropathic Pain

Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Claerhout, Stijn; Sharma, Sweta; Sköld, Christian; Cavaluzzo, Claudia et al.

Ingår i Tetrahedron, s. 3019-3029, 2012.

DOI för Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

Sköld, Christian; Kleimark, Jonatan; Trejos, Alejandro; Odell, Luke R. et al.

Ingår i Chemistry - A European Journal, s. 4714-4722, 2012.

DOI för Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids Ladda ner fulltext (pdf) av Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

Gising, Johan; Nilsson, Mikael T; Odell, Luke R; Yahiaoui, Samir et al.

Ingår i Journal of Medicinal Chemistry, s. 2894-2898, 2012.

DOI för Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors Ladda ner fulltext (pdf) av Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

From the First Selective Non-Peptide AT(2) Receptor Agonist to Structurally Related Antagonists

Andappan, Murugaiah M. S.; Wu, Xiongyu; Wallinder, Charlotta; Mahalingam, A. K. et al.

Ingår i Journal of Medicinal Chemistry, s. 2265-2278, 2012.

DOI för From the First Selective Non-Peptide AT(2) Receptor Agonist to Structurally Related Antagonists

Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Svensson, Fredrik; Karlén, Anders; Sköld, Christian

Ingår i Journal of Chemical Information and Modeling, s. 225-232, 2012.

DOI för Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Nordqvist, Anneli; Nilsson, Mikael T.; Lagerlund, Olof; Muthas, Daniel et al.

Ingår i MedChemComm, s. 620-626, 2012.

DOI för Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Angiotensin II, a neuropeptide at frontier between endocrinology and neuroscience:  is there a link between the angiotensin II type 2 receptor andAlzheimer’s disease?

Gallo-Payet, Nicole; Guimond, Marie-Odile; Bilodeau, Lyne; Wallinder, Charlotta et al.

Ingår i Frontiers in Endocrinology, s. Article 17-, 2011.

DOI för Angiotensin II, a neuropeptide at frontier between endocrinology and neuroscience:  is there a link between the angiotensin II type 2 receptor andAlzheimer’s disease?

The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system

Ohsawa, Masahiro; Carlsson, Anna; Asato, Megumi; Koizumi, Takayuki et al.

Ingår i Molecular Pain, s. 85-, 2011.

DOI för The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system Ladda ner fulltext (pdf) av The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system

Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis

Andaloussi, Mounir; Lindh, Martin; Björkelid, Christofer; Suresh, Surisetti et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 5403-5407, 2011.

DOI för Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis

Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

Nordqvist, Anneli; Björkelid, Christofer; Andaloussi, Mounir; Jansson, Anna M. et al.

Ingår i Journal of Organic Chemistry, s. 8986-8998, 2011.

DOI för Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors Ladda ner fulltext (pdf) av Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

P2-P1 ' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Lampa, Anna; Ehrenberg, Angelica E.; Vema, Aparna; Åkerblom, Eva et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 4917-4927, 2011.

DOI för P2-P1 ' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase

Andaloussi, Mounir; Henriksson, Lena M.; Wieckowska, Anna; Lindh, Martin et al.

Ingår i Journal of Medicinal Chemistry, s. 4964-4976, 2011.

DOI för Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase Ladda ner fulltext (pdf) av Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase

Non-peptide AT2-receptor agonists

Steckelings, U. Muscha; Larhed, Mats; Hallberg, Anders; Widdop, Robert E. et al.

Ingår i Current opinion in pharmacology (Print), s. 187-192, 2011.

DOI för Non-peptide AT2-receptor agonists

The effect of substance P1-7 amide on nociceptive threshold in diabetic mice

Ohsawa, Masahiro; Carlsson, Anna; Asato, Megumi; Koizumi, Takayuki et al.

Ingår i Peptides, s. 93-98, 2011.

DOI för The effect of substance P1-7 amide on nociceptive threshold in diabetic mice

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

Andersson, Hanna; Demaegdt, Heidi; Johnsson, Anders; Vauquelin, Georges et al.

Ingår i Journal of Medicinal Chemistry, s. 3779-3792, 2011.

DOI för Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

Hepatitis C protease inhibitors based on 2(1H)-pyrazinones

Gising, Johan; Belfrage, Anna Karin; Örtqvist, Pernilla; Larhed, Mats et al.

Ingår i Abstracts of Papers of the American Chemical Society, s. 116-MEDI-, 2010.

Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1-7

Fransson, Rebecca; Botros, Milad; Sköld, Christian; Nyberg, Fred et al.

Ingår i Journal of Medicinal Chemistry, s. 2383-2389, 2010.

DOI för Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1-7

Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Ax, Anna; Joshi, Advait A.; Orrling, Kristina M.; Vrang, Lotta et al.

Ingår i Tetrahedron, s. 4049-4056, 2010.

DOI för Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition

Mahalingam, A. K.; Wan, Yiqian; Murugaiah, A. M. S.; Wallinder, Charlotta et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 4570-4590, 2010.

DOI för Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition

Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Örtqvist, Pernilla; Vema, Aparna; Ehrenberg, Angelica E; Dahl, Göran et al.

Ingår i Antiviral Therapy, s. 841-852, 2010.

DOI för Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Lampa, Anna; Ehrenberg, Angelica E.; Gustafsson, Sofia S.; Vema, Aparna et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5413-5424, 2010.

DOI för Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)

Andersson, Hanna; Demaegdt, Heidi; Vauquelin, Georges; Lindeberg, Gunnar et al.

Ingår i Journal of Medicinal Chemistry, s. 8059-8071, 2010.

DOI för Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)

Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase

Ericsson, Daniel J.; Nurbo, Johanna; Muthas, Daniel; Hertzberg, Kalle et al.

Ingår i Journal of Peptide Science, s. 159-164, 2010.

DOI för Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase

Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Örtqvist, Pernilla; Gising, Johan; Ehrenberg, Angelica; Vema, Aparna et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6512-6525, 2010.

DOI för Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Synthesis and evaluation of a ¹¹C-labelled angiotensin II AT₂ receptor ligand

Åberg, Ola; Stevens, Marc; Lindh, Jonas; Wallinder, Charlotta et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, s. 616-624, 2010.

DOI för Synthesis and evaluation of a ¹¹C-labelled angiotensin II AT₂ receptor ligand

Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Bergström, Christel A S; Bolin, Sara; Artursson, Per; Rönn, Robert et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 556-563, 2009.

DOI för Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones

Gising, Johan; Örtqvist, Pernilla; Sandström, Anja; Larhed, Mats

Ingår i Organic and biomolecular chemistry, s. 2809-2815, 2009.

DOI för A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones

Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

Odell, Luke R.; Nilsson, Mikael T.; Gising, Johan; Lagerlund, Olof et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 4790-4793, 2009.

DOI för Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

The C-terminal amidated analogue of the Substance P (SP) fragment SP (1-7) attenuates the expression of naloxone- precipitated withdrawal in morphine dependent rats

Zhou, Qin; Carlsson, Anna; Botros, Milad; Fransson, Rebecca et al.

Ingår i Peptides, s. 2418-2422, 2009.

DOI för The C-terminal amidated analogue of the Substance P (SP) fragment SP (1-7) attenuates the expression of naloxone- precipitated withdrawal in morphine dependent rats

Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

Nilsson, Mikael T.; Krajewski, Wojciech W.; Srinivasa, Bachally R.; Yahiaoui, Samir et al.

Ingår i Journal of Molecular Biology, s. 504-513, 2009.

DOI för Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors Ladda ner fulltext (pdf) av Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

New developments in the discovery of agents to treat hepatitis C

Rönn, Robert; Sandström, Anja

Ingår i Current Topics in Medicinal Chemistry, s. 533-562, 2008.

DOI för New developments in the discovery of agents to treat hepatitis C

Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2

Andersson, Hanna; Demaegdt, Heidi; Vauquelin, Georges; Lindeberg, Gunnar et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6924-6935, 2008.

DOI för Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2

Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

Nordqvist, Anneli; Nilsson, Mikael T.; Röttger, Svenja; Odell, Luke R. et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5501-5513, 2008.

DOI för Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery Ladda ner fulltext (pdf) av Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering?: An investigation of the advantages and pitfalls of post-filtering

Muthas, Daniel; Sabnis, Yogesh A; Lundborg, Magnus; Karlén, Anders

Ingår i Journal of Molecular Graphics and Modelling, s. 1237-1251, 2008.

DOI för Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering?: An investigation of the advantages and pitfalls of post-filtering

Small peptides mimicking substance P (1-7) and encompassing a C-terminal amide functionality

Fransson, Rebecca; Botros, Milad; Nyberg, Fred; Lindeberg, Gunnar et al.

Ingår i Neuropeptides, s. 31-37, 2008.

DOI för Small peptides mimicking substance P (1-7) and encompassing a C-terminal amide functionality

Chemistry and folding of photomodulable peptides: stilbene and thioaurone-type candidates for conformational switches

Erdélyi, Máté; Varedian, Miranda; Sköld, Christian; Niklasson, Ida B. et al.

Ingår i Organic and biomolecular chemistry, s. 4356-4373, 2008.

DOI för Chemistry and folding of photomodulable peptides: stilbene and thioaurone-type candidates for conformational switches

Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening

Jacobsson, Micael; Gäredal, Magnus; Schultz, Johan; Karlén, Anders

Ingår i Journal of Medicinal Chemistry, s. 2777-2786, 2008.

DOI för Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening

Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships

Wallinder, Charlotta; Botros, Milad; Rosenström, Ulrika; Guimond, Marie-Odile et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6841-6849, 2008.

DOI för Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships

Wallinder, Charlotta

Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

2008.

Ladda ner fulltext (pdf) av Wallinder, Charlotta

β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors

Nurbo, Johanna; Peterson, Shane D.; Dahl, Göran; Danielson, U. Helena et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5590-5605, 2008.

DOI för β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors

Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Sköld, Christian; Nikiforovich, Gregory; Karlén, Anders

Ingår i Journal of Molecular Graphics and Modelling, s. 991-1003, 2008.

DOI för Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety

Rönn, Robert; Lampa, Anna; Peterson, Shane D.; Gossas, Thomas et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 2955-2967, 2008.

DOI för Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

Luzhkov, Victor B.; Selisko, Barbara; Nordqvist, Anneli; Peyrane, Frédéric et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 7795-7802, 2007.

DOI för Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3

Dahl, Göran; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

Ingår i Antiviral Therapy, s. 733-740, 2007.

Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3

Dahl, Göran; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

Ingår i The FEBS Journal, s. 5979-5986, 2007.

DOI för Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3

Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Rönn, Robert; Gossas, Thomas; Sabnis, Yogesh A.; Daoud, Hanna et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 4057-4068, 2007.

DOI för Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3

Poliakov, Anton; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

Ingår i Journal of enzyme inhibition and medicinal chemistry (Print), s. 191-199, 2007.

DOI för Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3

Focused hierarchical design of peptide libraries - follow the lead

Muthas, Daniel; Lek, Per M.; Nurbo, Johanna; Karlén, Anders et al.

Ingår i Journal of Chemometrics, s. 486-495, 2007.

DOI för Focused hierarchical design of peptide libraries - follow the lead

Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

Lagerlund, Olof; Odell, Luke R.; Mowbray, Sherry L.; Nilsson, Mikael T. et al.

Ingår i Combinatorial chemistry & high throughput screening, s. 783-789, 2007.

DOI för Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach

Sunnerheim, Kerstin; Nordqvist, Anneli; Nordlander, Göran; Borg-Karlson, Anna-Karin et al.

Ingår i Journal of Agricultural and Food Chemistry, s. 9365-9372, 2007.

DOI för Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach

Selective angiotensin II AT(2) receptor agonists devoid of the imidazole ring system

Murugaiah, A. M. S.; Wallinder, Chalotta; Mahalingam, A. K.; Wu, Xiongyu et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 7166-7183, 2007.

DOI för Selective angiotensin II AT(2) receptor agonists devoid of the imidazole ring system

Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor

Axén, Andreas; Andersson, Hanna; Lindeberg, Gunnar; Rönnholm, Harriet et al.

Ingår i Journal of Peptide Science, s. 434-444, 2007.

DOI för Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor

Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase

Nurbo, Johanna; Roos, Annette K; Muthas, Daniel; Wahlström, Erik et al.

Ingår i Journal of Peptide Science, s. 822-832, 2007.

DOI för Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase

Sköld, Christian

Computational Modeling of the AT₂ Receptor and AT₂ Receptor Ligands: Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models

2007.

Ladda ner fulltext (pdf) av Sköld, Christian

Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Georgsson, Jennie; Sköld, Christian; Botros, Milad; Lindeberg, Gunnar et al.

Ingår i Journal of Medicinal Chemistry, s. 1711-1715, 2007.

DOI för Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Sköld, Christian; Karlén, Anders

Ingår i Journal of Molecular Graphics and Modelling, s. 145-153, 2007.

DOI för Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors

Örtqvist, Pernilla; Peterson, Shane D.; Åkerblom, Eva; Gossas, Thomas et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 1448-1474, 2007.

DOI för Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors

Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Ingår i Journal of Medicinal Chemistry, s. 6133-6137, 2006.

DOI för Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

Fast and selective synthesis of novel cyclic sulfamide HIV-1 purchase inhibitors under controlled microwave heating

Gold, H; Ax, A; Vrang, L; Samuelsson, B et al.

Ingår i Tetrahedron, s. 4671-4675, 2006.

Ligand bias of scoring functions in structure-based virtual screening.

Jacobsson, Micael; Karlén, Anders

Ingår i J Chem Inf Model, s. 1334-43, 2006.

Improved CoMFA modeling by optimization of settings.

Peterson, Shane D; Schaal, Wesley; Karlén, Anders

Ingår i J Chem Inf Model, s. 355-64, 2006.

Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies.

Skold, Christian; Winiwarter, Susanne; Wernevik, Johan; Bergstrom, Fredrik et al.

Ingår i J Med Chem, s. 6660-71, 2006.

Selective angiotensin II AT(2) receptor agonists: Arylbenzylimidazole structure-activity relationships

Wu, Xiongyu; Wan, Yiqian; Mahalingam, A. K.; Murugaiah, A. M. S. et al.

Ingår i Journal of Medicinal Chemistry, s. 7160-7168, 2006.

DOI för Selective angiotensin II AT(2) receptor agonists: Arylbenzylimidazole structure-activity relationships

Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

Rönn, Robert; Sabnis, Yogesh A; Gossas, Thomas; Åkerblom, Eva et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 544-559, 2006.

DOI för Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

Short pseudopeptides containing turn scaffolds with high AT(2) receptor affinity

Georgsson, Jennie; Rosenström, Ulrika; Wallinder, Charlotta; Beaudry, Hélène et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5963-5972, 2006.

DOI för Short pseudopeptides containing turn scaffolds with high AT(2) receptor affinity

A New Structural Theme in C2-Symmetric HIV-1 Protease Inhibitors: ortho-Substituted P1/P1’ Side Chains

Wannberg, Johan; Sabnis, Yogesh A.; Vrang, Lotta; Samuelsson, Bertil et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5303-5315, 2006.

New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

Rosenström, Ulrika; Sköld, Christian; Plouffe, Bianca; Beaudry, Hélène et al.

Ingår i Journal of Medicinal Chemistry, s. 4009-4024, 2005.

DOI för New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

A new tool in peptide engineering: a photoswitchable stilbene-type beta-hairpin mimetic.

Erdélyi, Máté; Karlén, Anders; Gogoll, Adolf

Ingår i Chemistry, s. 403-12, 2005.

Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II.

Muthas, Daniel; Nötteberg, Daniel; Sabnis, Yogesh A; Hamelink, Elizabeth et al.

Ingår i Bioorg Med Chem, s. 5371-90, 2005.

Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2' to P1/P1'.

Ax, Anna; Schaal, Wesley; Vrang, Lotta; Samuelsson, Bertil et al.

Ingår i Bioorg Med Chem, s. 755-64, 2005.

Design, Synthesis, and Biological Evaluation of the First Selective Nonpeptide AT2 Receptor Agonist

Wan, Yigian; Wallinder, Charlotta; Plouffe, Bianca; Beaudry, Hélène et al.

Ingår i Journal of Medicinal Chemistry, s. 5995-6008, 2004.

DOI för Design, Synthesis, and Biological Evaluation of the First Selective Nonpeptide AT2 Receptor Agonist

First Reported Nonpeptide AT1 Receptor Agonist (L-162,313) Acts as an AT2 Receptor Agonist in Vivo

Wan, Yigian; Wallinder, Charlotta; Johansson, Berndt; Holm, Mathias et al.

Ingår i Journal of Medicinal Chemistry, s. 1536-1546, 2004.

DOI för First Reported Nonpeptide AT1 Receptor Agonist (L-162,313) Acts as an AT2 Receptor Agonist in Vivo

Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.

Roos, Annette K; Andersson, C Evalena; Bergfors, Terese; Jacobsson, Micael et al.

Ingår i J Mol Biol, s. 799-809, 2004.

AT2-selective angiotensin II analogues containing tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.

Johannesson, Petra; Erdelyi, Mate; Lindeberg, Gunnar; Frändberg, Per-Anders et al.

Ingår i J Med Chem, s. 6009-19, 2004.

Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors.

Afzelius, Lovisa; Zamora, Ismael; Masimirembwa, Collen M; Karlen, Anders et al.

Ingår i J Med Chem, s. 907-14, 2004.

Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques.

Afzelius, Lovisa; Raubacher, Florian; Karlen, Anders; Jørgensen, Flemming Steen et al.

Ingår i Drug Metab Dispos, s. 1218-29, 2004.

Synthesis and AT2 receptor-binding properties of angiotensin II analogues

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Ingår i Journal of Peptide Research, s. 194-201, 2004.

DOI för Synthesis and AT2 receptor-binding properties of angiotensin II analogues

A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Ingår i Journal of Medicinal Chemistry, s. 859-870, 2004.

DOI för A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Poliakov, Anton; Johansson, Anja; Åkerblom, Eva; Oscarsson, Karin et al.

Ingår i Biochimica et Biophysica Acta, s. 51-59, 2004.

DOI för Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-length NS3 (protease-helicase/NTPase): a comparative study of different C-terminals

Johansson, Anja; Poliakov, Anton; Åkerblom, Eva; Wiklund, Karin et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 2551-2568, 2003.

DOI för Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-length NS3 (protease-helicase/NTPase): a comparative study of different C-terminals

Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-melphalanyl-p-L-fluorophenylalanine ethyl ester): Comparison with its m-L-sarcolysin analogue P2

Gullbo, Joachim; Wallinder, Charlotta; Tullberg, Marcus; Lövborg, Henrik et al.

Ingår i Molecular Cancer Therapeutics, s. 1331-1339, 2003.

Johansson, Anja

Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors

2003.

Ladda ner fulltext (pdf) av Johansson, Anja

Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor

Johannesson, Petra; Lindeberg, Gunnar; Johansson, Anja; Nikiforovich, Gregory V et al.

Ingår i Journal of Medicinal Chemistry, s. 1767-1777, 2002.

DOI för Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor

Tetrapeptides as potent protease inhibitors of Hepatitis C Virus full-length NS3 (protease-helicase/NTPase)

Johansson, Anja; Poliakov, Anton; Åkerblom, Eva; Lindeberg, Gunnar et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 3915-22, 2002.

DOI för Tetrapeptides as potent protease inhibitors of Hepatitis C Virus full-length NS3 (protease-helicase/NTPase)

Effects of cholesterol and model transmembrane proteins on drugpartitioning into lipid bilayers as analysed by immobilized-liposomechromatography.

Lagerquist, C; Beigi, F; Karlen, A; Lennernas, H et al.

Ingår i J Pharm Pharmacol, s. 1477-, 2001.

Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

Johansson, Anja; Hubatsch, Ina; Åkerblom, Eva; Lindeberg, Gunnar et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 203-206, 2001.

DOI för Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen

Hämäläinen, Markku D.; Markgren, Per-Olof; Schaal, Wesley; Karlén, Anders et al.

Ingår i Journal of Biomolecular Screening, s. 353-359, 2000.

DOI för Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen

An Improved Procedure for N- to C-Directed (Inverse) Solid-Phase Peptide Synthesis

Johansson, Anja; Åkerblom, Eva; Ersmark, Karolina; Lindeberg, Gunnar et al.

Ingår i Journal of combinatorial chemistry, s. 496-507, 2000.

DOI för An Improved Procedure for N- to C-Directed (Inverse) Solid-Phase Peptide Synthesis

Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains

Hultén, Johan; Andersson, Hans O.; Schaal, Wesley; Danielson, U. Helena et al.

Ingår i Journal of Medicinal Chemistry, s. 4054-4061, 1999.

DOI för Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains

Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor

Bäckbro, Kristina; Löwgren, Seved; Österlund, Katrin; Atepo, Johnson et al.

Ingår i Journal of Medicinal Chemistry, s. 898-902, 1997.

DOI för Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor

Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol

Niklasson, Gunilla; Kvarnström, Ingemar; Classon, Björn; Samuelsson, Bertil et al.

Ingår i Journal of carbohydrate chemistry, s. 555-569, 1996.

DOI för Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol