Publication list

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Uppsala University

Uppsala, Sweden


L. P. Conway, N. Garg, W. Lin, M. Vujasinovic, J.-M. Löhr, D. Globisch

Chem. Comm. 201955, 9080-9083.

Chemoselective Probe for Detailed Analysis of Ketones and Aldehydes Produced by Gut Microbiota in Human Samples


M. S. P. Correia, M. Rao, C. Ballet, D. Globisch

ChemBioChem 201920, 1678-1683.

Enzymatic and mass spectrometric analysis for selective identification of glucuronidated metabolites in human samples

Featured in the ChemBioTalents Issue.


L. P. Conway, M. S. P. Correia, D. Globisch

GIT Laboratory Journal  2019.

Hunting Gut Microbiota Metabolites - Elucidating the Metabolic Interplay with Their Human Host


M. S. P. Correia+, C. Ballet+, H. Meistermann,  L. P. Conway, D. Globisch

Bioorg. Med. Chem. 201927, 955-962.

Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry


N. Garg+, L. P. Conway+, C. Ballet, M. S. P. Correia, F. K. S. Olsson, M. Vujasinovic, J.-M. Löhr, D. Globisch

Angew. Chem. Int. Ed. 201857, 13805-13809​.

Chemoselective Probe Harboring a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism

Highlighted in the SciLifeLab News


C. Ballet+, M. S. P. Correia+, L. P. Conway, T. L. Locher, L. C. Lehmann, N. Garg, M. Vujasinovic, S. Deindl, J.-M. Löhr, D. Globisch

Chem. Sci. 20189, 6233-6239.

New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites


R. J. Shirey, D. Globisch, L. M. Eubanks, M. S. Hixon, K. D. Janda

ACS Infect. Dis. 2018, 4, 1423-1431.​

Non-Invasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis


N. Garg, A. Hansson, H. K. Knych, S. D. Stanley, M. Thevis, U. Bondesson, M. Hedeland, D. Globisch

Org. Biomol. Chem. 2018, 16, 698-702.

Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control

The Scripps Research Institute

La Jolla, CA, USA 


D. Globisch*, L. M. Eubanks, R. J. Shirey, K. M. Pfarr, S. Wanji, A. Y. Debrah, A. Hoerauf, K. D. Janda

Bioorg. Med. Chem. Lett. 2017, 27, 3436-3440.

"Validation of Onchocerciasis Biomarker N-Acetyltyramine-O-glucuronide (NATOG)"


K. Tsuchikama, M. Gooyit, T. L. Harris, J. Zhu, D. Globisch, G. F. Kaufmann, K. D. Janda

Angew. Chem. Int. Ed. 2016, 55, 4002-4006.

Glycation Reactivity of a Quorum-Sensing Signaling Molecule


D. Globisch, S. Specht, K. M. Pfarr, Lisa M. Eubanks, A. Hoerauf, K. D. Janda

Bioorg. Med. Chem. Lett. 2015, 25, 5804-5807.

Litomosoides sigmodontis: A Jird Urine Metabolome Study


X. Cai, D. Globisch, P. Thompson, J. Lin, D. Toader, N. Dimasi, C. Gao, K. D. Janda

Tetrahedron Lett. 2015, 56, 3172-3175.

A chemoenzymatic approach toward the preparation of site-specific antibody–drug conjugates


J. W. Lockner, L. Eubanks, J. M. Lively, J. Choi, J. E. Schlosburg, K. C. Collins, D. Globisch, R. J. Rosenfeld-Gunn, I. A. Wilson, K. D. Janda

Mol. Pharmacol. 2015, 12, 653-662.

Flagellin Protein as Carrier and Adjuvant in a Cocaine Vaccine


J. Zhu, M. S. Hixon, D. Globisch, G. F. Kaufmann, K. D. Janda

J. Am. Chem. Soc. 2013, 135, 7827-7830.

Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation


D. Globisch, A. Y. Moreno, M. S. Hixon, A. A. K. Nunes, J. R. Denery, S. Specht, A. Hoerauf, K. D. Janda

Proc. Natl. Acad. Sci. U S A. 2013, 110, 4218-4223.

Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness

Selected as Cover Image: Proc. Natl. Acad. Sci. U S A. 2013, 110 (11).

Research Highlight in Nature 2013, 495, 8; News of the Week in Chem. & Eng. News 2013, 91, 11; Science Now in Science February 2013.


D. Globisch, C. A. Lowery, K. C. McCague, K. D. Janda

Angew. Chem. Int. Ed. 2012, 51, 4204-4208; Angew. Chem. 2012, 124, 4280-4284.

Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species

  • Selected as Inside Back Cover: Angew. Chem. Int. Ed. 2012, 51, 4239.
  • Very Important Paper; Spotlight in ACS Chem. Biol. 2012, 7, 789-790; Highlight in Angew. Chem. Int. Ed. 2012, 51, 6314-6315.


J. S. Zakhari, I. Kinoyama, M. S. Hixon, A. Di Mola, D. Globisch, K. D. Janda

Bioorg. Med. Chem. 2011, 19, 6203-6209.

Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4‑diaminopyridine prodrug design and characterization

Ludwig-Maximilians-University Munich

Munich, Germany 


C. Brandmayr, M. Wagner, T. Brückl, D. Globisch, D. Pearson, A. C. Kneuttinger, V. Reiter, A. Hienzsch, S. Koch, I. Thoma, P. Thumbs, S. Michalakis, M. Müller, M. Biel, T. Carell

Angew. Chem. Int. Ed. 2012, 51, 11162-11165; Angew. Chem. 2012, 124, 11324-11328.

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency


T. F. Kraus+, D. Globisch+, M. Wagner, S. Eigenbrod, D. Widmann, M. Münzel, M. Müller, T. Pfaffeneder, B. Hackner, W. Feiden, U. Schüller, T. Carell, H. A. Kretzschmar

Int. J. Cancer 2012, 131, 1577-1590.

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base", are associated with anaplasia in human brain tumors

+: These authors contributed equally


V. Reiter, D. Matschkal, M. Wagner, D. Globisch, A. Kneuttinger, M. Müller, T. Carell

Nucleic Acids Res. 2012, 40, 6235-6240.

The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA


D. Globisch, D. Pearson, A. Hienzsch, T. Brückl, M. Wagner, I. Thoma, P. Thumbs, V. Reiter, A. C. Kneuttinger, M. Müller, S. A. Sieber, T. Carell

Angew. Chem. Int. Ed. 2011, 50, 9739-9742; Angew. Chem. 2011, 123, 9913-9916.

Systems-Based Analysis of Modified tRNA Bases

  • Selected as Hot Paper.


M. Münzel+, D. Globisch+, T. Carell

Angew. Chem. Int. Ed. 2011, 50, 6460-6468; Angew. Chem. 2011, 123, 6588-6596.

5-Hydroxymethylcytosine, the Sixth Base of the Genome” (Minireview)

+: These authors contributed equally


M. Münzel, C. Szeibert, A. F. Glas, D. Globisch, T. Carell

J. Am. Chem. Soc. 2011, 133, 5186-5189.

Discovery and Synthesis of a new UV-induced Intrastrand C(4-8)G Photolesion


D. Pearson, A. Hienzsch, M. Wagner, D. Globisch, V. Reiter, D. Özden, T. Carell

Chem. Comm. 2011, 47, 5196-5198.

LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA


D. Globisch+, M. Münzel+, M. Müller, S. Michalakis, M. Wagner, S. Koch, T. Brückl, M. Biel, T. Carell

PLoS One 2010, 5, e15367.

> 435 citations

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

+: These authors contributed equally


M. Münzel, D. Globisch, C. Trindler, T. Carell

Org. Lett. 2010, 12, 5671-5673.

Efficient Synthesis of 5-Hydroxymethylcytosine Containing DNA


M. Münzel+, D. Globisch+, T. Brückl, M. Wagner, V. Welzmiller, S. Michalakis, M. Müller, M. Biel, T. Carell

Angew. Chem. Int. Ed. 2010, 49, 5375-5377; Angew. Chem. 2010, 122, 5503-5505.

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

  • Highlight in Chem. Eng. News 2010, 88 (No 27), 24; Selected as Hot Paper.

+: These authors contributed equally


T. Brückl+, D. Globisch+, M. Wagner, M. Müller, T. Carell

Angew. Chem. Int. Ed. 2009, 48, 7932-7934; Angew. Chem. 2009, 121, 8074-8077.

Parallel Isotope-Based Quantification of Modified tRNA Nucleosides

  • Highlight in Chem. Eng. News 2009, 87 (No 38), 35; Selected as Hot Paper.

+: These authors contributed equally

University of Southern Denmark

Odense, Denmark 


Y. M. Loksha, D. Globisch, R. Loddo, G. Collu, P. La Colla, E. B. Pedersen

ChemMedChem 2010, 5, 1847-1849.

A Novel Synthetic Route for the Anti-HIV Drug MC-1220 and its Analogues


D. Globisch, N. Bomholt, V. V. Filichev, E. B. Pedersen

Helv. Chim. Acta 2008, 91, 805-818.

Stability of Hoogsteen Type triplexes – Electrostatic attraction between duplex backbone and TFO using an intercalating conjugate


Y. M. Loksha, D. Globisch, E. B. Pedersen, P. La Colla, G. Collu, R. Loddo

J. Heterocycl. Chem. 2008, 45, 1161-1166.

Synthesis and Anti-HIV-1 Evaluation of 1,5-Disubstituted Pyrimidine-2,4-diones

Conference Articles 


G.M. Ferri, C.M. Harvey, D. Globisch, K.D. Janda, K.N. Allen

FASEB J. 201832 :674.16.

Using M. marinum T6PP as a Model for M. tuberculosis Inhibitor Design


C. Harvey, C. Liu, D. Globisch, K.D. Janda, D. Dunaway-Mariano, K. Allen

FASEB J. 201731 :923.5.

Trehalose-6-Phosphate Phosphatase Structure and Inhibitor Design


E. B. Pedersen, A.M.A. Osman, D. Globisch, M. Paramasiva, S. Cogoi, N. Bomholt, P.T. Jørgensen, L.E. Xodo, V.V. Filichev

Nucleic Acids Symp Ser (Oxf) 200852 37-38.

Triplex glue by synthesizing conjugated flexible intercalators