Uppsala's MSI environment continues to expand
Just a minute… Per Andrén, Professor of Medical Mass Spectrometry, that with the installation of a new FTICR instrument heads of one of the world's leading facilities for Mass Spectrometry Imaging.
What's going on at Lab Per Andrén?
“We have just installed a new mass spectrometer of the model solariX MALDI FTICR 7T, an extremely powerful instrument for Mass Spectrometry Imaging (MSI). It generates ultrahigh mass resolution, a necessary property in order to image the complex environment that a biological tissue section constitutes. Together with the first FTICR instrument that we acquired in 2018 and our other instruments, we now have one of the world's leading laboratories in our field.”
What services do you provide?
“With MSI technology, we can determine the distribution of molecules - especially metabolites, lipids, peptides, small proteins and drugs - in thin sections of biological tissue, for example in different organs. We collaborate with preclinical and clinical researchers, but also perform services to the pharmaceutical industry in the development of new drugs. The fact that our team also has the interdisciplinary competence to design, execute, compile and evaluate entire projects makes us an internationally attractive resource. Currently, there is a queue to our facility, but with this new instrument we increase our capacity significantly.”
What is required to engage you?
“An interesting project, granted funding and potential for high impact publications. We always start with a planning meeting and examine whether the substance or drug in question is compatible with our technology. After that we test ionization on tissue accompanied by a pilot project, and if everything looks good, we move to full scale. We are currently involved in about forty studies, mainly in Sweden, but we also have several international clients.”
Why did you choose Uppsala for your facility?
“After my postdoc at MSI pioneer Richard Caprioli's laboratory in Houston, USA, I divided my time between GE Healthcare and Uppsala University until 2010. In 2003, I received funding to build an MSI facility at BMC. Over the years, the Swedish Research Council, SSF, the Wallenberg Foundation and several other organisations have funded us, and today we have the mechanical equipment to offer the latest technology.”
What are your plans for the near future?
“We continuously develop methods for visualizing molecules that are difficult to image. In collaboration with Luke Odell, we recently presented in Nature Method's new chemical tools to be able to simultaneously image a large number of neurotransmitters in different regions of the brain. The method provides a better overall picture of how the brain's chemical messengers interact in basic neurological processes and in disease states. We also have several collaborations that we strongly believe in, for example with Per Svenningsson, neurologist at KI, with ENABLE - the EU's investment in the development of new antibiotics - and of course with researchers at our own faculty. In addition, we conduct our own research focusing on Parkinson's disease and L-Dopa-induced dyskinesias, as well as new MSI methods for drugs and their effects.”
Facts Mass Spectrometry Imaging (MSI)
- Enables analysis and visualisation of endogenous metabolites, neurotransmitters, lipids, peptides and small proteins as well as drugs and their metabolites, in thin biological tissue sections with high molecular specificity.
- Molecular images are created by ionizing molecules and collecting mass spectra from each position (pixels) on a tissue surface at a selected lateral resolution. Thousands of ions can be detected in each pixel.
- The distribution of individual molecules on the surface of the tissue is then extracted and a molecule-specific image is created. The image can be correlated with the original histological image or images produced with other types of imaging methods from the same or nearby tissue sections.
- Visit online Research in Medical Mass Spectrometry at Uppsala University
- Also read Mass spectrometry imaging identifies abnormally elevated brain L-DOPA levels and extrastriatal monoaminergic dysregulation in L-DOPA–induced dyskinesia
- Also read Comprehensive mapping of neurotransmitter networks by MALDI–MS imaging
- Also read New findings on adverse effects of L-Dopa therapy of Parkinson's disease
Per Andrén, Professor of Medical Mass Spectrometry
Department of Pharmaceutical Biosciences
Uppsala's MSI environment continues to expand
Just a minute… Per Andrén, Professor of Medical Mass Spectrometry, that with the installation of a new FTICR instrument heads of one of the world's leading facilities for Mass Spectrometry Imaging.
New route for foreign pharmacists to Swedish labor market a success
In 2017, Uppsala University launched a Complementary Programme and a Proficiency test for newly arrived pharmacists. Today, the participants account for one in four applications for Swedish pharmacist licenses. "Everyone is extremely motivated," says Shima Momemi, coordinator at the Faculty of Pharmacy.
Testa Center takes your life science to the next level
As a researcher or teacher in life sciences at Uppsala University, you have access to Testa Center's high-quality laboratory environments. Here you will meet the infrastructure and expertise you need to take your innovations and students to new heights.
Nominate your candidate for The Distinguished Teaching Awards
Which teacher at the Faculty of Pharmacy has made the most outstanding contributions in undergraduate education? Nominate your candidate for the Uppsala University Distinguished Teaching Awards 2021 no later than 18 March.
New findings on adverse effects of L-Dopa therapy of Parkinson's disease
To treat Parkinson's disease with L-Dopa will gradually deteriorate in effect and cause involuntary movements. In a new study, researchers at Uppsala University link this to a dysregulation of L-Dopa metabolism throughout the brain.
Interdisciplinary collaboration provides new answers about immunity after Covid-19
Only weeks after the coronavirus reached Sweden, blood samples were taken from more than 2,000 employees at Danderyd Hospital. Today, a selection of the country's leading researchers collaborate with this unique material within the COMMUNITY study to extract new knowledge needed to fight covid-19.
New methods to predict release and absorption of orally administered drugs
Friday 15 January at 09.15 Caroline Alvebratt, PhD student at the Department of Pharmacy, will defend her dissertation with focus on new methods to predict the release and absorption of orally administered drugs. Welcome to participate online via Zoom.
Sooraj Bajinath wins Bioanalysis Rising Star Award 2020
Sooraj Baijnath, researcher of Medical Mass Spectrometry Imaging, is the winner of the Bioanalysis Rising Star Award 2020. “It has been overwhelming to see the amount of support I have received globally,” says Sooraj Baijnath.
They won the Faculty's X-mas gift competition 2020
The Christmas gift competition is over and three co-workers can end this strange year in the best possible way. With the WHO's assurance that Santa, despite his considerable age, is immune to all viruses, we dare to promise that the gifts will be delivered in time before holiday leave.
New thesis explores the evolution of sponge species in Antarctica and the deep sea
Thursday 17 December at 1 PM, Vasiliki Koutsouveli, PhD student at the Department of Pharmaceutical Biosciences, will defend her thesis focusing on the ecophysiological and evolutionary aspects of sponge species from Antarctica and the deep sea. Welcome to participate online via Zoom.
New analysis method for predicting the risks and effects of immunotherapy
In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphatic leukaemia. This has awakened hopes that this analysis method could pave the way for important breakthroughs in immunotherapy research and treatment.
ERC Grant for research on new method to diagnose and treat inflammatory bowel disease
Just a minute… Alexandra Teleki, researcher in drug development, who receives 2 million euros from the European Research Council to develop a new method to diagnose and treat inflammatory bowel disease in children.
Apply now for the Swedish Pharmaceutical Society scholarships
Post docs, PhD:s & Students in the field of pharmacy can now apply for scholarships for, among other things, research courses and congresses. Apply no later than 31 January 2021.
Be a winner in this year's X-mas gift competition
With glühwein and a well deserved vacation just weeks away, the Faculty of Pharmacy strikes with the hottest event of the year: The X-mas gift competition 2020. Three lucky winners will receive an extra present in their stockings that will make them the department's most admired employees the entire 2021.
Ebba Bergman and Phil Harrison win the Adipocyte Cell Imaging Challenge
Ebba Bergman and Phil Harrison, PhD students at the Department of Pharmaceutical Biosciences, are winners of the Adipocyte Cell Imaging Challenge – AI Sweden and AstraZeneca's challenge to create a solution to avoid using staining when testing new drugs on cell cultures.
New research raises hope of curing Alzheimer's disease
"Our ambition is to apply the method to humans in the foreseeable future," says Greta Hultqvist, researcher at Uppsala University, who with a new protein transporter has succeeded in stopping and reversing the development of Alzheimer's disease in mice.
Here, pharmaceutical experts are educated to make Swedish healthcare even more efficient
With the task to optimise each patient's drug situation, the clinical pharmacists have in a short time become a welcome reinforcement in the Regions' care teams. At Uppsala University, Sweden's only Master's Programme in Clinical Pharmacy is offered, and the demand for the students' competence is high.
See webinar on the opportunities offered at Testa Center
At Testa Center, researchers and students at Uppsala University have access to modern equipment for drug and bioprocess development. In this webinar, recorded during Innovation Week 2020, experiences and examples of the work performed are presented. (webinar in Swedish)
SSF illustrates Erik Jansson's research in new film
Erik Jansson, researcher at the Department of Pharmaceutical Biosciences, explains in a new film from the Swedish Foundation for Strategic Research his work of increasing our knowledge of the body's signaling system between brain and cells.
Sara Mangsbo receives SITC Team Science Award
Sara Mangsbo, researcher at the Faculty of Pharmacy, receives the 2020 SITC Team Science Award for her work contributing to new cancer treatments.
The SweDeliver Scientific Advisory Board identifies great potential
“Our Scientific Advisory Board expressed that SweDeliver is moving in the right trajectory, providing a unique ecosystem with great potential to exceed the needs of all stakeholders,” states Christel Bergström, Center director at Sweden's new competence center for Drug delivery.
Swedish Research Council grants SEK 6.6 million to Daniel Globisch and Ola Spjuth
Daniel Globisch and Ola Spjuth, researchers at Uppsala University's Faculty of Pharmacy, are granted a total of SEK 6.6 million in the Swedish Research Council's call Natural and engineering sciences. The grants are to be received during 2020–2024.
Elin Svedin is new chairwoman of the Alumni Association Farmis
Just a minute… Elin Svedin, who in the spring of 2020 graduated from Uppsala University's Master of Science Programme in Pharmacy and now takes over as chairwoman of the Alumni Association Farmis.
Eight months of distance learning: "We are approaching a critical point"
March 18th, Uppsala University switched to distance teaching and examination. Eight months later, the BMC seminar halls and corridors still offer desolate experiences. How does this affect teachers and students, Anja Sandström, Deputy dean for first and second cycle education at the Faculty of Pharmacy.
Sara Mangsbo: Prize-winning innovator focused on immunotherapy
Over the past decade, more and more biopharmaceuticals have been developed for anti-cancer immunotherapy. Sara Mangsbo is actively contributing to their development with her research group, and has also started three companies. She was recently awarded the Uppsala University Innovation Prize, Hjärnäpplet, for her ability to combine research and entrepreneurship.
Two new awards to researchers at the Faculty of Pharmacy
Maria Karlgren and Christine Wegler, researchers at the Faculty of Pharmacy, receive awards for their work contributing to reduce the number of animal studies and increased knowledge about drug disposition in the liver and small intestine.
Swedish Research Council grants millions to research at the Faculty of Pharmacy
Per Artursson, Olof Eriksson, Hans Lennernäs and Ola Spjuth, researchers at Uppsala University's Faculty of Pharmacy, have been granted a total of SEK 16.68 million in the Swedish Research Council's call Medicine and Health. The grants will be received during 2020–2024.
Uppsala researcher in EU-initiative for better medication adherence
Getting patients to take their drugs correctly is one of healthcare's biggest and oldest challenges. Now experts from 39 European countries are joining forces in the ENABLE project to make a difference. "We have good conditions for success," says Björn Wettermark, Professor of Pharmacoepidemiology.
SweDeliver's junior researchers prepare their next career step
With a focus on lifelong learning, SweDeliver's young researchers participate in a selection of activities within the Work package Training and Career Development. First on the schedule is a series of digital lunch seminars and a Mentoring program in collaboration with the center's industrial partners
Per Artursson: If we are to aim for the top, we must tear down the glass ceiling
Standing on the shoulders of giants, we will allegedly discover the way forward, so if one would ever cross our path, it would be a mistake not to try the view. Per Artursson, Professor of Dosage Form Design and Giant of Pharmaceutical Sciences, works at Uppsala Biomedical Centre, and the perspectives offered are undeniably interesting.
The Diversity report: Varying images that require further analysis
“The Disciplinary domain's Diversity report points at great opportunities at the Faculty of Pharmacy, but to take full advantage of them require further analysis,” says Hooshang Bazrafshan, equal opportunities specialist at Uppsala University.
New model to provide more accurate predictions in drug treatment
With a new and more accurate computational model for how the drug rosuvastatin (Crestor ®) is taken up and eliminated in the liver, researchers at Uppsala University paves the way for more efficient drug development and future treatment methods.
New study aim to provide safer oral administration of macromolecular drugs
"Our project is developing in a very positive direction," says Staffan Berg, PhD Student at SweDeliver that, with base at both AstraZeneca R&D and Uppsala's Faculty of Pharmacy, hopes to add new knowledge to one of pharmaceutical research's oldest challenges.
Present your research at SciFest 2021
The Uppsala science festival SciFest goes digital. March 1–6, 2021, researchers from Uppsala University and curious schoolchildren and adults from all over Sweden will meet for a variety of lectures, shows and activities. As a researcher at the Faculty of Pharmacy, you can now register your participation.
New facility takes up the chase for doped athletes and future drugs
Using a home-grown filamentous fungus, Mikael Hedeland, professor of analytical pharmaceutical chemistry, managed to expose four medalists guilty of doping at the Olympic Games in Athens. Now he is refining his methods further, opening a facility for mass spectrometry at the Uppsala Biomedical Center.
Self-learning machines take the step into drug discovery
In the winter of 2020, a novel robotised laboratory for cell profiling will open at Uppsala's Biomedical Centre – a high-tech facility ready to deliver as the Knut and Alice Wallenberg Foundation now invests SEK 3.1 billion in making Sweden a world leader in computer-driven life sciences.
Se onlineseminarium om problemspelande i en föränderlig omvärld
I oktober inbjöd Uppsala universitets Forum för forskning om läkemedels- och drogberoende (U-FOLD) och Svenska Spels oberoende Forskningsråd till Öppen Forskningsdag i syfte att belysa det senaste inom forskningsområdet kring hasardspel. Experter vid flera universitet och högskolor deltar i mötet som du nu kan se online.
SEK 9 million to research on personalized drugs for children suffering from severe diseases
Christel Bergström, Professor of Molecular Pharmaceutics, receives SEK 9 million from the Erling-Persson Family Foundation in continued support of the project Personalized medications for children suffering from severe diseases.
New method enables earlier answers during drug development
With the Nobel Prize-winning technology CRISPR-Cas9, researchers at Uppsala University are creating new components for more efficient drug development with fewer animal experiments.
Researchers at the Faculty of Pharmacy praise this year's selection of Nobel Laureates
To contribute to better treatment and reducing the spread of the viral disease hepatitis C is prioritized work at Uppsala University's Faculty of Pharmacy, where researchers praise the 2020 selection of Nobel laureates in physiology or medicine.
The SweDeliver Pulmonary Drug Delivery Work Package – An ecosystem for research and competence development
“The national competence center SweDeliver has already extended the visibility and appeal of the Faculty of Pharmacy far beyond Sweden's borders. This enhances our ability to recruit top-of-the-line PhD students and postdocs.”, states Göran Frenning, Professor of Pharmaceutical Physics and leader of the Pulmonary Drug Delivery Work Package.
Webinar 7 December: Swedish pharmaceutical research and the way forward
On Monday 7 December, the Swedish Pharmaceutical Society and IF's foundation for pharmaceutical research invite you to a webinar with future explorations and retrospective aspects on how Sweden will regain its leading position in the world of pharmaceuticals.
Former Vice-rector Stellan Sandler is awarded the Gustaf Adolf Medal
Stellan Sandler, professor of medical cell biology and former Vice-rector at the Disciplinary Domain of Medicine and Pharmacy, is awarded the older Gustaf Adolf Medal in gold for his significant contributions to Uppsala University.
What’s on at the Faculty? – 13 October 2020
Welcome to What’s on at the Faculty of Pharmacy? We will meet online via Zoom. The program contains current issues, our faculty’s diversity report and popular science presentations. We will end with coffee&quiz at BMC.
The Faculty of Pharmacy congratulates its newly graduated pharmaceutical experts
A new generation of pharmaceutical experts has received their diplomas and is entering their professional life. Saturday 26 September, the Faculty of Pharmacy held the 2020 graduation ceremony - which this year was four.
Webinar 6 October: Testa Center and Uppsala University developing for required cutting-edge competence
At Testa Center, students at Uppsala University receive training in bioprocess- and drug development, while researchers get access to modern equipment in the biotechnological process industry. In this webinar at Innovation Week 2020, students and researchers talk about their experiences at the Testa Center.
Apply for travel grant for travels April–September 2021
Apply no later than 15 October for the Vice-Chancellor’s travel grant for travels April–September 2021. Grants are awarded for travels that most benefit a personal scholarly exchange and is of use to Swedish research.
Sofia Kälvemark Sporrong: Sweden needs more pharmacy rebels
Eleven years after the deregulation of the pharmacy market, Sweden is facing another comprehensive reform. Now with healthcare in focus. And once again, a distinct pharmaceutical voice is missing in the debate. "It is time for the profession to make themselves heard," says Sofia Kälvemark Sporrong, Professor of Social pharmacy, returning to Sweden and Uppsala University.
Researcher profile: Sara Mangsbo explores new ways to fight cancer
At the forefront of one of science's most successful fields. Entrepreneur of the year and ready to give another company a flying start. Sara Mangsbo, researcher in immune-oncology at Uppsala University, follows her own advice and looks far beyond the comfort zone.
The SweDeliver Oral Drug Delivery work package – A gold mine for junior researchers
“Here, PhD Students and postdocs interact with leading research groups, aspiring start-ups and established companies. It is a dynamic environment that will ensure continued growth in the already dynamic Swedish life science sector.”
Vice-rector Mats Larhed: What we do now will shape our disciplinary domain for many years to come
After nine years as deputy Vice-rector, Mats Larhed takes the next step. The To-do list is extensive and 5-6 October, he will gather the disciplinary domain staff and students for Vision: Medfarm. An initiative that will point out a mutual direction forward.
SweDeliver Parenteral drug delivery – Home to a diversity of high-quality research
At SweDeliver's research environment for parenteral drug delivery, industry and Uppsala University's Faculty of Pharmacy meet to develop new systems for injected drug administration. It is an arena characterized by commitment, trust and a mutual movement forward.
Watch U-FOLD seminar on gambling addiction during the Corona crisis
Wednesday 16 September, U-FOLD focused on gambling problems and addiction in relation to aggressive advertising, mental illness and Covid-19. The webseminar was attended by, among others, Minister for Social Security Ardalan Shekarabi (S).
Digital (bad)habits present new challenges to addiction researchers
Hundreds of thousands of Swedes caught in the web of online casinos. Children who sit glued to screens, risking their future physical and mental health. New technologies have made the path to addiction more of a maze than ever before.
New knowledge about NAT2–enzyme can help improve drug dosages
Researchers at Uppsala University have identified previously unknown activity in the enzyme NAT2 affecting the body's metabolism and clearance of drugs. The study, expected to contribute to tailor-made drug treatments, is published in Angewandte Chemie International Edition.
Continued increase in applicants for the Master of Science Programme in Pharmacy
In the second selection for admissions to the autumn term, 115 students were admitted to the Faculty of Pharmacy's Master of Science Programme in Pharmacy. 90 students were admitted to the Bachelor of Science Programme in Pharmacy.
Dean Mathias Hallberg: We must enhance the visibility of the Faculty of Pharmacy
On 1 July, new managements were installed at Uppsala University's faculties and disciplinary domains. The new dean of the Faculty of Pharmacy is Mathias Hallberg, professor of molecular life sciences, whose first task is to guide our operations through the ongoing reorganization.
Farmis invites to annual alumni meeting
Farmis invites to annual alumni meeting 28 September 2020. The meeting will include an exclusive lecture with researcher and entrepreneur Sara Mangsbo. Participate on site in Segerstedthuset or online via link. Please register no later than 26 September.
Deputy Dean Anja Sandström: We must work together to raise the number of applicants for our educations
Just a minute… Anja Sandström, since 1 July Deputy dean for first and second cycle education at the Faculty of Pharmacy.
The Faculty of Pharmacy launches new structure
“I am confident that in the foreseeable future we will work in a very creative environment,” says Mathias Hallberg, dean of Uppsala University's Faculty of Pharmacy, where seven research groups are entering a new scientific environment.
Faculty of Pharmacy facing the future with optimism
The playing field has been redrawn many times since Sweden's only Faculty of Pharmacy was established at Uppsala University, but neither political squalls nor industrial giants in exile prevent researchers at Uppsala Biomedicine Center from facing the future with optimism.
Apply for the Swedish Pharmaceutical Society's scholarships no later than 31 October
The Swedish Pharmaceutical Society announces available scholarships aimed at PhD:s for participation in conferences and courses as well as for Postdoc stays abroad. Students can apply for a travel grant to conduct a degree project abroad. Welcome with your application no later than 31 October 2020.
SweDeliver is shaping the future of drug delivery
This summer, SweDeliver – Sweden's first national competence center in drug delivery – was inaugurated. With the hub at Uppsala University's Faculty of Pharmacy, academia and industry will cooperate to push the boundaries for the development of new pharmaceuticals.
Here we present more news from the Faculty of Pharmacy at Uppsala University: