Department of Medicinal Chemistry

Associate Professor Daniel Globisch, Ph.D.

                                                    Short Curriculum Vitae
 

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orcid.org/0000-0002-4526-5788

Education and Professional Research:

  • 09/2015 – present    Uppsala University                                        

  • 04/2011 – 08/2015   The Scripps Research Institute (TSRI), La Jolla, CA  
    • Group of Professor Kim D. Janda

  • 03/2007 – 03/2011   Ludwig-Maximilians-University (LMU) of Munich        
    • Group of Professor Thomas Carell

  • 04/2006 – 01/2007   University of Southern Denmark                   
  • 04/2005 – 07/2005  
    • Group of Professor Erik B. Pedersen

  • 10/2001 – 03/2006   Technical University of Kaiserslautern             

Short Biography

Associate Professor Daniel Globisch started his independent research group in September 2015 at Uppsala University as a Science For Life Laboratory Fellow. He joined the Department of Medicinal Chemistry and has been awarded a starting grant from Vetenskåpsradet (VR) for four years. In April 2017 he has been appointed as Associate Professor.

Daniel studied Chemistry at the Technical University of Kaiserslautern / Germany. He completed his Diploma thesis in Organic Chemistry at the Nucleic Acids Research Center of the Southern University of Denmark in Odense, where he worked on HIV-1 inhibitors and triplex-forming oligonucleotides. Daniel defended his PhD thesis in Organic Chemistry in 2011 at the Ludwig-Maximilians-University in Munich. His research was focused on the synthesis and mass spectrometric quantification of natural modified transfer-RNA nucleosides and the epigenetic DNA marker 5-hydroxymethylcytosine, discovered in 2009. To extend his expertise and skills in Chemical Biology, Daniel joined The Scripps Research Institute to develop new strategies for the inhibition of bacterial Quorum Sensing holding a research grant from the German Academic Exchange Service (DAAD). During his postdoctoral research Daniel Globisch also discovered the small molecule biomarker N-acetyltyramine-O-glucuronide (NATOG) using a metabolomics mining approach for the neglected tropical disease onchocerciasis within the Worm Institute for Research and Medicine (WIRM). In his independent research projects at Uppsala University, he is developing new methodologies to extend the scope of metabolomics research to discover new biomarkers for pancreatic and colorectal cancer. The interdisciplinary nature of the research projects is focussed on the metabolic interaction between microbiota and their human host.


Selected publications

N. Garg+, L. P. Conway+, C. Ballet, M. S. P. Correia, F. K. S. Olsson; M. Vujasinovic, J.-M. Löhr, D. Globisch
Angew. Chem. Int. Ed. 2018accepted.
“Chemoselective Probe Harboring a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism”

C. Ballet+, M.S.P. Correia+, L.P. Conway, T.L. Locher, L.C. Lehmann, N. Garg, M. Vujasinovic, S. Deindl, J.M. Löhr, D. Globisch
Chem. Sci. 20189, 6233-6239. HOT paper
“New selective and mass spectrometric methodology for the investigation of gut microbiota-derived metabolites”

D. Globisch, A.Y. Moreno, M.S. Hixon, A.A.K. Nunes, J.R. Denery, S. Specht, A. Hoerauf, K.D. Janda
Proc. Natl. Acad. Sci. U S A. 2013, 110, 4218–4223. Cover Image
“Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness”

D. Globisch, C.A. Lowery, K.C. McCague, K.D. Janda 
Angew. Chem. Int. Ed. 2012, 51, 4204–4208. Inside Cover
“Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species“

D. Globisch, D. Pearson, A. Hienzsch, T. Brückl, M. Wagner, I. Thoma, P. Thumbs, V. Reiter, A.C. Kneuttinger, M. Müller, S.A. Sieber, T. Carell
Angew. Chem. Int. Ed. 2011, 50, 9739–9742; Angew. Chem. 2011, 123, 9913–9916. Hot Paper
“Systems-Based Analysis of Modified tRNA Bases”

M. Münzel+D. Globisch+, T. Brückl, M. Wagner, V. Welzmiller, S. Michalakis, M. Müller, M. Biel, T. Carell
Angew. Chem. Int. Ed. 2010, 49, 5375–5377. Hot Paper
“Quantification of the sixth DNA base hydroxymethylcytosine in the brain”