The research at the Division of Analytical Pharmaceutical Chemistry at the Department of Medicinal Chemistry is focused on separation science and mass spectrometry. The analytes of interest are drugs and their degradation products and metabolites including carbohydrates, peptides, proteins, amino acids as well as other small molecules.
The research is divided into two areas of importance: pharmaceutical analysis and bioanalysis. Over the last years the major emphasis has shifted from pharmaceutical analysis to bioanalysis.
Bioanalysis is the subdiscipline of analytical chemistry that covers the determination of drugs and their metabolites in biological systems. The research at the Division of Analytical Pharmaceutical Chemistry within this area covers investigation of the metabolic pattern of drugs in in vivo systems (i.e. human, horse), chiral and achiral analysis of drugs in the aquatic environment, the use of in vitro systems for production of metabolites as well as metabolomics studies in relation to diseases and nutrition.
Liquid chromatography hyphenated to high resolution mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy are the main techniques that are used within the projects in the bioanalysis field.